Literature DB >> 15837416

Regulation of Akt/PKB Ser473 phosphorylation.

Jose R Bayascas1, Dario R Alessi.   

Abstract

For years the Akt/PKB research field has been in turmoil, trying to understand how the activating phosphorylation of Akt/PKB at Ser473 is regulated. In the past month, papers in a recent issue of Molecular Cell (Gao et al., 2005) and in Science (Sarbassov et al., 2005) may have identified the phosphatase and kinase acting on this residue.

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Year:  2005        PMID: 15837416     DOI: 10.1016/j.molcel.2005.03.020

Source DB:  PubMed          Journal:  Mol Cell        ISSN: 1097-2765            Impact factor:   17.970


  70 in total

Review 1.  The role of mTOR in memory CD8 T-cell differentiation.

Authors:  Koichi Araki; Ben Youngblood; Rafi Ahmed
Journal:  Immunol Rev       Date:  2010-05       Impact factor: 12.988

2.  Phase I clinical, pharmacokinetic, and pharmacodynamic study of the Akt-inhibitor triciribine phosphate monohydrate in patients with advanced hematologic malignancies.

Authors:  Deepa Sampath; Asifa Malik; William Plunkett; Billie Nowak; Betsy Williams; Michelle Burton; Srdan Verstovsek; Stefan Faderl; Guillermo Garcia-Manero; Alan F List; Said Sebti; Hagop M Kantarjian; Farhad Ravandi; Jeffrey E Lancet
Journal:  Leuk Res       Date:  2013-08-06       Impact factor: 3.156

Review 3.  Inhibition of mitogen-activated protein kinase and stimulation of Akt kinase signaling pathways: Two approaches with therapeutic potential in the treatment of neurodegenerative disease.

Authors:  Robert E Burke
Journal:  Pharmacol Ther       Date:  2007-02-27       Impact factor: 12.310

4.  Edwardsiella piscicida Enters Nonphagocytic Cells via a Macropinocytosis-Involved Hybrid Mechanism.

Authors:  Tianjian Hu; Lingzhi Zhang; Wei Wang; Dahai Yang; Jingfan Xiao; Yuanxing Zhang; Xiaohong Liu; Qin Liu
Journal:  J Bacteriol       Date:  2019-02-11       Impact factor: 3.490

5.  Brain cancer stem cells display preferential sensitivity to Akt inhibition.

Authors:  Christine E Eyler; Wen-Chi Foo; Katherine M LaFiura; Roger E McLendon; Anita B Hjelmeland; Jeremy N Rich
Journal:  Stem Cells       Date:  2008-09-18       Impact factor: 6.277

6.  A novel Epac-Rap-PP2A signaling module controls cAMP-dependent Akt regulation.

Authors:  Kyoungja Hong; Liguang Lou; Sandhya Gupta; Fernando Ribeiro-Neto; Daniel L Altschuler
Journal:  J Biol Chem       Date:  2008-06-12       Impact factor: 5.157

7.  Dual inhibition of PI3K and mTOR inhibits autocrine and paracrine proliferative loops in PI3K/Akt/mTOR-addicted lymphomas.

Authors:  Aadra P Bhatt; Prasanna M Bhende; Sang-Hoon Sin; Debasmita Roy; Dirk P Dittmer; Blossom Damania
Journal:  Blood       Date:  2010-03-18       Impact factor: 22.113

Review 8.  Programmed cell death and new discoveries in the genetics of parkinsonism.

Authors:  Robert E Burke
Journal:  J Neurochem       Date:  2007-12-10       Impact factor: 5.372

Review 9.  The Role of PI3K/Akt and ERK in Neurodegenerative Disorders.

Authors:  Sachchida Nand Rai; Hagera Dilnashin; Hareram Birla; Saumitra Sen Singh; Walia Zahra; Aaina Singh Rathore; Brijesh Kumar Singh; Surya Pratap Singh
Journal:  Neurotox Res       Date:  2019-02-01       Impact factor: 3.911

10.  Peptidyl-prolyl cis/trans isomerase Pin1 is critical for the regulation of PKB/Akt stability and activation phosphorylation.

Authors:  Y Liao; Y Wei; X Zhou; J-Y Yang; C Dai; Y-J Chen; N K Agarwal; D Sarbassov; D Shi; D Yu; M-C Hung
Journal:  Oncogene       Date:  2009-05-18       Impact factor: 9.867

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