| Literature DB >> 15837357 |
Simmaly Phongmany1, Rattanaphone Phetsouvanh, Siho Sisouphone, Chirapha Darasavath, Pankham Vongphachane, Oudayvone Rattanavong, Mayfong Mayxay, Andrew C Ramsay, Stuart D Blacksell, Chanpheng Thammavong, Bounkong Syhavong, Nicholas J White, Paul N Newton.
Abstract
We conducted a randomized open trial of oral chloramphenicol (50mg/kg/day in four divided doses for 14 days) versus ofloxacin (15 mg/kg/day in two divided doses for 3 days) in 50 adults with culture-confirmed uncomplicated typhoid fever in Vientiane, Laos. Patients had been ill for a median (range) of 8 (2-30) days. All Salmonella enterica serotype typhi isolates were nalidixic acid-sensitive, four (8%) were chloramphenicol-resistant and three (6%) were multidrug-resistant. Median (range) fever clearance times were 90 (24-224) hours in the chloramphenicol group and 54 (6-93) hours in the ofloxacin group (P<0.001). One patient in the chloramphenicol group developed an ileal perforation. Three days ofloxacin was more effective than 14 days chloramphenicol for the in-patient treatment of typhoid fever, irrespective of antibiotic susceptibility, and was of similar cost.Entities:
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Year: 2005 PMID： 15837357 DOI： 10.1016/j.trstmh.2004.08.007
Source DB: PubMed Journal: Trans R Soc Trop Med Hyg ISSN： 0035-9203 Impact factor: 2.184