| Literature DB >> 15837332 |
Colin A Lowery1, Kathleen M McKenzie, Longwu Qi, Michael M Meijler, Kim D Janda.
Abstract
Quorum sensing activity was investigated in the bacterium Vibrio harveyi using a series of both natural and nonnatural analogs of DPD, the penultimate precursor to autoinducer AI-2. The progression of molecules that were both synthesized and investigated includes enantiomeric variants, carbon-chain extension, and hydroxyl-functional group addition/deletions of DPD. The compilation of these studies reveals a binding cleft that can accommodate a number of different structural variants of DPD, albeit with invariably lower activities.Entities:
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Year: 2005 PMID： 15837332 DOI： 10.1016/j.bmcl.2005.02.069
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823