Literature DB >> 15837319

N-Hydroxy sulfonimidamides as new nitroxyl (HNO) donors.

Richard L Pennington1, Xin Sha, S Bruce King.   

Abstract

Chlorination and condensation of simple sulfinamides with O-benzyl and O-tert-butyl dimethyl siloxy hydroxylamine gives O-protected N-hydroxy sulfonimidamides. Deprotection of these compounds produces the corresponding sulfinamide and nitrous oxide, which provides evidence for the intermediacy of nitroxyl (HNO) and identifies these compounds as new potential HNO donors.

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Year:  2005        PMID: 15837319     DOI: 10.1016/j.bmcl.2005.02.082

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  3 in total

Review 1.  The chemistry of nitroxyl-releasing compounds.

Authors:  Jenna F DuMond; S Bruce King
Journal:  Antioxid Redox Signal       Date:  2011-03-02       Impact factor: 8.401

2.  Dual mechanisms of HNO generation by a nitroxyl prodrug of the diazeniumdiolate (NONOate) class.

Authors:  Daniela Andrei; Debra J Salmon; Sonia Donzelli; Azadeh Wahab; John R Klose; Michael L Citro; Joseph E Saavedra; David A Wink; Katrina M Miranda; Larry K Keefer
Journal:  J Am Chem Soc       Date:  2010-10-29       Impact factor: 15.419

3.  Xerogel optical sensor films for quantitative detection of nitroxyl.

Authors:  Kevin P Dobmeier; Daniel A Riccio; Mark H Schoenfisch
Journal:  Anal Chem       Date:  2008-01-16       Impact factor: 6.986

  3 in total

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