Y Y Yu1, Q Li, Z G Zhu. 1. Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, China. yingyan3y@yahoo.com.cn
Abstract
AIM: To describe the role of nuclear factor-kappa B (NF-kappaB) in cancer treatment. METHODS: We searched the Pubmed database (until Oct, 2004) with the keywords of gastrointestinal carcinoma, NF-kappaB, inhibitor, cancer treatment molecular target and chemoresistance. We reviewed the literature in the role of NF-kappaB activation in chemoresistance, tumour growth suppression and enhancement of apoptosis in gastrointestinal carcinomas. CONCLUSIONS: Several possible strategies for inhibiting NF-kappaB activation are identified. The importance of targeting NF-kappaB as a potential therapeutic approach in clinical medicine was discussed.
AIM: To describe the role of nuclear factor-kappa B (NF-kappaB) in cancer treatment. METHODS: We searched the Pubmed database (until Oct, 2004) with the keywords of gastrointestinal carcinoma, NF-kappaB, inhibitor, cancer treatment molecular target and chemoresistance. We reviewed the literature in the role of NF-kappaB activation in chemoresistance, tumour growth suppression and enhancement of apoptosis in gastrointestinal carcinomas. CONCLUSIONS: Several possible strategies for inhibiting NF-kappaB activation are identified. The importance of targeting NF-kappaB as a potential therapeutic approach in clinical medicine was discussed.
Authors: A E S Simões; D M Pereira; S E Gomes; H Brito; T Carvalho; A French; R E Castro; C J Steer; S N Thibodeau; C M P Rodrigues; P M Borralho Journal: Cell Death Dis Date: 2015-04-09 Impact factor: 8.469
Authors: Ji Qi; C K Tan; Saeed M Hashimi; Abu Hasanat Md Zulfiker; David Good; Ming Q Wei Journal: Evid Based Complement Alternat Med Date: 2014-03-06 Impact factor: 2.629