| Literature DB >> 15836517 |
H Dommisch1, J Winter, Y Açil, A Dunsche, M Tiemann, S Jepsen.
Abstract
The purpose of this study was to investigate the expression of human beta-defensins (hBD-1, -2) in dental pulps by reverse-transcription polymerase chain reaction (RT-PCR) and immunohistochemistry. The mRNA transcripts of human beta-defensin-1 and human beta-defensin-2 could be detected by performing RT-PCR. With immunohistochemical staining of pulp tissue using antisera to hBD-1 and -2 it was possible to demonstrate cytoplasmic expression in odontoblasts. The results demonstrate that not only oral keratinocytes at the epithelial surface but also odontoblasts express human beta-defensins. Thus odontoblasts take part in the innate immune system and human beta-defensins may play an important role in the innate host defense of human dental pulp.Entities:
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Year: 2005 PMID： 15836517 DOI： 10.1111/j.1399-302X.2005.00206.x
Source DB: PubMed Journal: Oral Microbiol Immunol ISSN： 0902-0055