Literature DB >> 1583642

Confirmation of genetic linkage between atopic IgE responses and chromosome 11q13.

R P Young1, P A Sharp, J R Lynch, J A Faux, G M Lathrop, W O Cookson, J M Hopkin.   

Abstract

Genetic linkage between atopic IgE responses and chromosome 11q13 (D11S97) has been previously reported in a limited number of extended families. Difficulties of phenotyping in the older family members, poor family structure in some families, and genetic heterogeneity were proposed as possible explanations for the variability in lod scores. To test this finding a second linkage study of 64 young nuclear families was undertaken and gave a two point lod score of 3.8 at theta = 0.07 (assuming theta m = theta f). A test of genetic heterogeneity in the nuclear families shows that atopic IgE responses are linked to this locus in 60 to 100% of families (approximate 95% confidence limits).

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Year:  1992        PMID： 1583642      PMCID： PMC1015920          DOI： 10.1136/jmg.29.4.236

Source DB:  PubMed          Journal:  J Med Genet        ISSN： 0022-2593            Impact factor:   6.318


  16 in total

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  23 in total

Review 1.  Breathing freely: the need for asthma research on gene-environment interactions.

Authors:  R L Miller
Journal:  Am J Public Health       Date:  1999-06       Impact factor: 9.308

2.  Linkage and association studies of atopy and the chromosome 11q13 region.

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Journal:  J Med Genet       Date:  1999-05       Impact factor: 6.318

3.  Evidence for asthma susceptibility genes on chromosome 11 in an African-American population.

Authors:  Shau-Ku Huang; Rasika A Mathias; Eva Ehrlich; Beverly Plunkett; Xin Liu; Garry R Cutting; Xin-Jing Wang; Xiao-Dong Li; Alkis Togias; Kathleen C Barnes; Floyd Malveaux; Stephen Rich; Beverly Mellen; Ethan Lange; Terri H Beaty
Journal:  Hum Genet       Date:  2003-03-27       Impact factor: 4.132

4.  Linkage/association study of a locus modulating total serum IgE on chromosome 14q13-24 in families with asthma.

Authors:  A H Mansur; D T Bishop; S T Holgate; A F Markham; J F J Morrison
Journal:  Thorax       Date:  2004-10       Impact factor: 9.139

5.  Association of an intragenic microsatellite marker in the CC16 gene with asthma in the Indian population.

Authors:  Shilpy Sharma; Balaram Ghosh
Journal:  J Hum Genet       Date:  2004-11-12       Impact factor: 3.172

Review 6.  Molecular biology and genetics of allergy and asthma.

Authors:  G G Anderson; J F Morrison
Journal:  Arch Dis Child       Date:  1998-05       Impact factor: 3.791

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Journal:  Thorax       Date:  1996-01       Impact factor: 9.139

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Journal:  Genome Res       Date:  1997-08       Impact factor: 9.043

9.  Genetic polymorphisms of the beta 2-adrenergic receptor in nocturnal and nonnocturnal asthma. Evidence that Gly16 correlates with the nocturnal phenotype.

Authors:  J Turki; J Pak; S A Green; R J Martin; S B Liggett
Journal:  J Clin Invest       Date:  1995-04       Impact factor: 14.808

10.  Genetic mapping studies of 40 loci and 23 cosmids in chromosome 11p13-11q13, and exclusion of mu-calpain as the multiple endocrine neoplasia type 1 gene.

Authors:  J T Pang; S E Lloyd; C Wooding; B Farren; B Pottinger; B Harding; S E Leigh; M A Pook; F J Benham; G T Gillett; R T Taggart; R V Thakker
Journal:  Hum Genet       Date:  1996-06       Impact factor: 4.132
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