Literature DB >> 15834965

The detection of modafinil and its major metabolite in equine urine by liquid chromatography/mass spectrometry.

Andrew R McKinney1, Craig J Suann, Allen M Stenhouse.   

Abstract

A method has been developed for the detection of modafinil and its major metabolite, modafinil acid, in equine urine by solid-phase extraction and positive ion electrospray ionisation liquid chromatography/mass spectrometry. The method has been applied to the analysis of equine urine samples obtained after the oral administration of modafinil. Modafinil acid was the major component in the urine, and was detected up to 4 days post-administration. Unchanged modafinil was present at substantially lower concentrations, and was detected for only 24 hours. Copyright 2005 John Wiley & Sons, Ltd.

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Year:  2005        PMID: 15834965     DOI: 10.1002/rcm.1910

Source DB:  PubMed          Journal:  Rapid Commun Mass Spectrom        ISSN: 0951-4198            Impact factor:   2.419


  5 in total

1.  Smart stability indicating spectrophotometric methods for determination of modafinil: the promising treatment for post-covid neurological syndrome.

Authors:  Soha G Elsheikh; Sally S El-Mosallamy; Yasmin M Fayez; Abeer M E Hassan
Journal:  BMC Chem       Date:  2022-10-21

Review 2.  High-performance liquid chromatography-tandem mass spectrometry in the identification and determination of phase I and phase II drug metabolites.

Authors:  M Holcapek; L Kolárová; M Nobilis
Journal:  Anal Bioanal Chem       Date:  2008-03-15       Impact factor: 4.142

3.  Quantitative determination of armodafinil in human plasma by liquid chromatography-electrospray mass spectrometry: Application to a clinical study.

Authors:  Hardik Chandasana; Johannes Kast; Janina A Bittman; Hartmut Derendorf
Journal:  Biomed Chromatogr       Date:  2018-08-07       Impact factor: 1.902

4.  Identification of adrafinil and its main metabolite modafinil in human hair. Self-administration study and interpretation of an authentic case.

Authors:  Alice Ameline; Laurie Gheddar; Jean-Sébastien Raul; Pascal Kintz
Journal:  Forensic Sci Res       Date:  2020-01-29

5.  Serial-omics characterization of equine urine.

Authors:  Min Yuan; Susanne B Breitkopf; John M Asara
Journal:  PLoS One       Date:  2017-10-13       Impact factor: 3.240

  5 in total

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