Literature DB >> 15834859

Glutathione-S-transferase-1 and interleukin-1beta gene polymorphisms in Japanese patients with Parkinson's disease.

Masataka Nishimura1, Sadako Kuno, Ryuji Kaji, Katsuhito Yasuno, Hideshi Kawakami.   

Abstract

We studied genetic polymorphisms in the glutathione-S-transferase-1 (GST-1) gene region and the interleukin-1beta (IL-1beta) promoter region in patients with Parkinson's disease (PD, n = 361), as well as controls (n = 257). Although we have confirmed the previous results, in a larger sample, that the IL-1beta genotype has affected the age at onset of PD patients, no contribution of the GST-1 gene polymorphism was observed in the allele frequency or the onset age of the disease in Japanese persons. Copyright 2005 Movement Disorder Society.

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Year:  2005        PMID： 15834859     DOI： 10.1002/mds.20477

Source DB:  PubMed          Journal:  Mov Disord        ISSN： 0885-3185            Impact factor:   10.338


  10 in total

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