M Yuzawa1, R Mori, A Kawamura. 1. Surugadai Hospital, Nihon University, Kanda, Chiyoda-ku, Tokyo, Japan. yuzawam@med.nihon-u.ac.jp
Abstract
BACKGROUND/AIM: There are two theories on the pathogenesis of polypoidal choroidal vasculopathy (PCV): variants in choroidal neovascularisation (CNV) and inner choroidal vessel abnormalities. On indocyanine green angiography (IGA) with a video camera system, PCV has a characteristic appearance, but inadequate image quality has made detailed interpretation difficult. This study aims to improve imaging, using confocal scanning laser ophthalmoscopy (SLO), to elucidate the pathogenesis of PCV. METHODS: High speed IGA with confocal SLO of 45 eyes (44 patients) showed typical PCV findings of a branching vascular network and polypoidal lesions. RESULTS: Vessels comprising branching networks began to fill simultaneously with the surrounding choroidal arteries in 38 eyes. Small numbers of vessels filling within a branching network, in the arterial and arteriovenous phases of IGA, showed focal dilatation, constriction, and tortuousity. Vessel abnormalities, corresponding to polypoidal lesions, existed within a network in eight eyes and included loops similar in calibre to network vessels, and numerous microaneurysmal dilatations of small vessels. Vessel pulsation was seen in 24 eyes. CONCLUSION: PCV is caused by inner choroidal vessel abnormalities, not CNV.
BACKGROUND/AIM: There are two theories on the pathogenesis of polypoidal choroidal vasculopathy (PCV): variants in choroidal neovascularisation (CNV) and inner choroidal vessel abnormalities. On indocyanine green angiography (IGA) with a video camera system, PCV has a characteristic appearance, but inadequate image quality has made detailed interpretation difficult. This study aims to improve imaging, using confocal scanning laser ophthalmoscopy (SLO), to elucidate the pathogenesis of PCV. METHODS: High speed IGA with confocal SLO of 45 eyes (44 patients) showed typical PCV findings of a branching vascular network and polypoidal lesions. RESULTS: Vessels comprising branching networks began to fill simultaneously with the surrounding choroidal arteries in 38 eyes. Small numbers of vessels filling within a branching network, in the arterial and arteriovenous phases of IGA, showed focal dilatation, constriction, and tortuousity. Vessel abnormalities, corresponding to polypoidal lesions, existed within a network in eight eyes and included loops similar in calibre to network vessels, and numerous microaneurysmal dilatations of small vessels. Vessel pulsation was seen in 24 eyes. CONCLUSION: PCV is caused by inner choroidal vessel abnormalities, not CNV.
Authors: L A Yannuzzi; D W Wong; B S Sforzolini; M Goldbaum; K C Tang; R F Spaide; K B Freund; J S Slakter; D R Guyer; J A Sorenson; Y Fisher; D Maberley; D A Orlock Journal: Arch Ophthalmol Date: 1999-11
Authors: L A Yannuzzi; K B Freund; M Goldbaum; B Scassellati-Sforzolini; D R Guyer; R F Spaide; D Maberley; D W Wong; J S Slakter; J A Sorenson; Y L Fisher; D A Orlock Journal: Ophthalmology Date: 2000-04 Impact factor: 12.079
Authors: K Takayama; Y Ito; H Kaneko; K Kataoka; T Sugita; R Maruko; K Hattori; E Ra; F Haga; H Terasaki Journal: Eye (Lond) Date: 2016-11-04 Impact factor: 3.775