Literature DB >> 15833820

Therapeutic targeting of the Hedgehog-GLI pathway in prostate cancer.

Pilar Sanchez1, Virginie Clement, Ariel Ruiz i Altaba.   

Abstract

The Hedgehog-GLI signaling pathway is important in animal development and tumorigenesis. Recent findings indicate that the growth and survival of human prostate cancer cells rely upon sustained signaling from the Hedgehog-GLI pathway. These findings have prompted a novel rational strategy for therapeutic treatment of prostate tumors, including metastatic tumors.

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Year:  2005        PMID： 15833820     DOI： 10.1158/0008-5472.CAN-05-0439

Source DB:  PubMed          Journal:  Cancer Res        ISSN： 0008-5472            Impact factor:   12.701


  34 in total

1.  Cytotoxic effects induced by docetaxel, gefitinib, and cyclopamine on side population and nonside population cell fractions from human invasive prostate cancer cells.

Authors:  Murielle Mimeault; Sonny L Johansson; Jean-Pierre Henichart; Patrick Depreux; Surinder K Batra
Journal:  Mol Cancer Ther       Date:  2010-02-23       Impact factor: 6.261

2.  Beta1 integrins mediate cell proliferation in three-dimensional cultures by regulating expression of the sonic hedgehog effector protein, GLI1.

Authors:  Hira Lal Goel; Jean M Underwood; Jeffrey A Nickerson; Chung-Cheng Hsieh; Lucia R Languino
Journal:  J Cell Physiol       Date:  2010-07       Impact factor: 6.384

3.  Sonic hedgehog-dependent induction of microRNA 31 and microRNA 150 regulates Mycobacterium bovis BCG-driven toll-like receptor 2 signaling.

Authors:  Devram Sampat Ghorpade; Sahana Holla; Srini V Kaveri; Jagadeesh Bayry; Shripad A Patil; Kithiganahalli Narayanaswamy Balaji
Journal:  Mol Cell Biol       Date:  2012-11-19       Impact factor: 4.272

4.  Intratumoral Heterogeneity of Frameshift Mutations of GLI1 Encoding a Hedgehog Signaling Protein in Colorectal Cancers.

Authors:  Ju Hwa Lee; Sang Yong Song; Min Sung Kim; Nam Jin Yoo; Sug Hyung Lee
Journal:  Pathol Oncol Res       Date:  2017-06-29       Impact factor: 3.201

Review 5.  Shared circuitry: developmental signaling cascades regulate both embryonic and adult coronary vasculature.

Authors:  Kory J Lavine; David M Ornitz
Journal:  Circ Res       Date:  2009-01-30       Impact factor: 17.367

6.  Hedgehog signaling is critical for maintenance of the adult coronary vasculature in mice.

Authors:  Kory J Lavine; Attila Kovacs; David M Ornitz
Journal:  J Clin Invest       Date:  2008-07       Impact factor: 14.808

7.  Hedgehog/Gli supports androgen signaling in androgen deprived and androgen independent prostate cancer cells.

Authors:  Mengqian Chen; Michael A Feuerstein; Elina Levina; Prateek S Baghel; Richard D Carkner; Matthew J Tanner; Michael Shtutman; Francis Vacherot; Stéphane Terry; Alexandre de la Taille; Ralph Buttyan
Journal:  Mol Cancer       Date:  2010-04-26       Impact factor: 27.401

8.  Expression of the glioma-associated oncogene homolog (GLI) 1 in human breast cancer is associated with unfavourable overall survival.

Authors:  Anette ten Haaf; Nuran Bektas; Sonja von Serenyi; Inge Losen; Elfriede Christel Arweiler; Arndt Hartmann; Ruth Knüchel; Edgar Dahl
Journal:  BMC Cancer       Date:  2009-08-25       Impact factor: 4.430

9.  Smoothened as a new therapeutic target for human osteosarcoma.

Authors:  Masataka Hirotsu; Takao Setoguchi; Hiromi Sasaki; Yukihiro Matsunoshita; Hui Gao; Hiroko Nagao; Osamu Kunigou; Setsuro Komiya
Journal:  Mol Cancer       Date:  2010-01-12       Impact factor: 27.401

10.  Gli1 maintains cell survival by up-regulating IGFBP6 and Bcl-2 through promoter regions in parallel manner in pancreatic cancer cells.

Authors:  Xuan-Fu Xu; Chuan-Yong Guo; Jun Liu; Wen-Juan Yang; Yu-Jing Xia; Ling Xu; Yong-Chun Yu; Xing-Peng Wang
Journal:  J Carcinog       Date:  2009
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