Literature DB >> 15832033

Evaluating associations between 5-HTTLPR polymorphism and Alzheimer's disease for Korean patients.

Tae Min Ha1, Deuk Man Cho, Sung Woo Park, Myung Jin Joo, Bong Ju Lee, Bo Geum Kong, Jae Min Kim, Jin Sang Yoon, Young Hoon Kim.   

Abstract

There has been growing evidence that the serotonin (5-HT) system is important in the regulation of memory and thus might be associated with Alzheimer's disease (AD), while research results on this issue have been inconsistent. The 5-HT system has also been suggested to be responsible for a significant portion of the behavioural aspects of AD. This study aimed to investigate the associations of the 5-HT transporter gene linked polymorphic region (5-HTTLPR) polymorphism with AD and delusional/aggressive symptoms of AD in Korean samples of 65 patients and 43 controls. The 5-HTTLPR polymorphism was neither associated with AD nor with delusional/aggressive symptoms of AD. It was suggested that phenotypic expression of the 5-HTTLPR polymorphism might be varied according to ethnic differences. Copyright (c) 2005 S. Karger AG, Basel.

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Year:  2005        PMID： 15832033     DOI： 10.1159/000085071

Source DB:  PubMed          Journal:  Dement Geriatr Cogn Disord        ISSN： 1420-8008            Impact factor:   2.959


  10 in total

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2.  The impact of serotonin transporter (5-HTTLPR) genotype on the development of resting-state functional connectivity in children and adolescents: a preliminary report.

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Review 4.  Genetics of psychosis in Alzheimer's disease: a review.

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Review 6.  Genetic determinants of aggression and impulsivity in humans.

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7.  Age-related effect of serotonin transporter genotype on amygdala and prefrontal cortex function in adolescence.

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9.  The association of 5HT2A and 5HTTLPR polymorphisms with Alzheimer's disease susceptibility: a meta-analysis with 6945 subjects.

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10.  Hydroxytryptamine transporter gene-linked polymorphic region (5HTTLPR) is associated with delusions in Alzheimer's disease.

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  10 in total

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