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Literature DB >> 15830840

Osteoblastic proliferative activity of Epimedium brevicornum Maxim.

F H Meng¹, Y B Li, Z L Xiong, Z M Jiang, F M Li.

Abstract

The effect of the extracts of Epimedium brevicornum Maxim. was investigated on proliferative activity in vitro. The osteoblast-like UMR106 cells was employed as an osteoblast model. The EtOH extract and the n-butanol fraction from the crude extract were found to show proliferation stimulating activity. Three flavonoid compounds (icariin, epimedin B and epimedin C) were isolated from this fraction by activity-guided assay, and the effects on cell proliferation were studied. Icariin produced the most significant promoting effect on the proliferation in osteoblast-like UMR106 cells. The results suggested that E. brevicornum Maxim. extracts might have potential activity against osteoporosis, and flavonoids such as icariin might be the active constituents stimulating osteoblasts.

Entities: Chemical Disease Species

Mesh：

Substances：
Plant Extracts

Year: 2005 PMID： 15830840 DOI： 10.1016/j.phymed.2004.03.007

Source DB: PubMed Journal: Phytomedicine ISSN： 0944-7113 Impact factor: 5.340

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Cited

25 in total

1. Icariin protects cardiomyocytes against ischaemia/reperfusion injury by attenuating sirtuin 1-dependent mitochondrial oxidative damage.

Authors: Bing Wu; Jian-Yu Feng; Li-Ming Yu; Yan-Chun Wang; Yong-Qing Chen; Yan Wei; Jin-Song Han; Xiao Feng; Yu Zhang; Shou-Yin Di; Zhi-Qiang Ma; Chong-Xi Fan; Xiao-Qin Ha
Journal: Br J Pharmacol Date: 2018-09-21 Impact factor: 8.739

2. Determination of Five Major 8-Prenylflavones in Leaves of Epimedium by Solid-Phase Extraction Coupled with Capillary Electrophoresis.

Authors: Juan-Ping Xie; Ji-Ming Xiang; Zhong-Liang Zhu
Journal: J Chromatogr Sci Date: 2016-02-09 Impact factor: 1.618

3. Icariside II promotes the osteogenic differentiation of canine bone marrow mesenchymal stem cells via the PI3K/AKT/mTOR/S6K1 signaling pathways.

Authors: Guangming Luo; Biao Xu; Yuanliang Huang
Journal: Am J Transl Res Date: 2017-05-15 Impact factor: 4.060

Osteoblastic proliferative activity of Epimedium brevicornum Maxim.

1. Icariin protects cardiomyocytes against ischaemia/reperfusion injury by attenuating sirtuin 1-dependent mitochondrial oxidative damage.

2. Determination of Five Major 8-Prenylflavones in Leaves of Epimedium by Solid-Phase Extraction Coupled with Capillary Electrophoresis.

3. Icariside II promotes the osteogenic differentiation of canine bone marrow mesenchymal stem cells via the PI3K/AKT/mTOR/S6K1 signaling pathways.

4. The effect of loading icariin on biocompatibility and bioactivity of porous β-TCP ceramic.

5. Icariside II promotes osteogenic differentiation of bone marrow stromal cells in beagle canine.

Review 6. The effect of icariin on bone metabolism and its potential clinical application.

7. Icariin stimulates the proliferation of rat bone mesenchymal stem cells via ERK and p38 MAPK signaling.

8. Changes in the intestinal absorption mechanism of icariin in the nanocavities of cyclodextrins.

9. Icaritin, an exogenous phytomolecule, enhances osteogenesis but not angiogenesis--an in vitro efficacy study.

10. Analysis of Molecular Mechanism of Erxian Decoction in Treating Osteoporosis Based on Formula Optimization Model.