Literature DB >> 15830489

Dihydrofolate reductase in Pediococcus cerevisiae strains susceptible and resistant to amethopterin.

F Mandelbaum-Shavit, N Grossowicz.   

Abstract

A mutant strain of Pediococcus cerevisiae was obtained which had 1,000-fold greater resistance to amethopterin than the P. cerevisiae/PteGlu strain. The dihydrofolate reductase level of the mutant was about 60-fold higher than that of the parent. The mutant accumulated folate, though less efficiently than its parent.

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Year:  1974        PMID： 15830489      PMCID： PMC444653          DOI： 10.1128/AAC.6.3.369

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  18 in total

1.  Dual consequence of mutation in the dihydrofolate reductase gene of Diplococcus pneumoniae.

Authors:  F M Sirotnak
Journal:  Biochem Biophys Res Commun       Date:  1969-08-15       Impact factor: 3.575

2.  Dihydrofolate reductase from amethopterin-resistant Lactobacillus casei.

Authors:  L E Gundersen; R B Dunlap; N G Harding; J H Freisheim; F Otting; F M Huennekens
Journal:  Biochemistry       Date:  1972-03-14       Impact factor: 3.162

3.  Effect of substrate decomposition on the spectrophotometric assay of dihydrofolate reductase.

Authors:  B L Hillcoat; P F Nixon; R L Blakley
Journal:  Anal Biochem       Date:  1967-11       Impact factor: 3.365

4.  Dihydrofolate reductase and thymidylate synthetase in strains of Streptococcus faecium resistant to pyrimethamine, chlorguanide triazine, trimethoprim, and amethopterin.

Authors:  J H Freisheim; C C Smith; P M Guzy
Journal:  Arch Biochem Biophys       Date:  1972-01       Impact factor: 4.013

5.  Purification and properties of dihydrofolate reductase from an amethopterin-resistant strain of Streptococcus faecium.

Authors:  L D'Souza; P E Warwick; J H Freisheim
Journal:  Biochemistry       Date:  1972-04-11       Impact factor: 3.162

6.  Purification, properties, and synthesis of dihydrofolate reductase from wild type and methotrexate-resistant hamster cells.

Authors:  H Nakamura; J W Littlefield
Journal:  J Biol Chem       Date:  1972-01-10       Impact factor: 5.157

7.  Studies on dihydrofolate reductase related to the drug sensitivity of microbial and neoplastic cells.

Authors:  C A Nichol
Journal:  Adv Enzyme Regul       Date:  1968

8.  Transport of folinate and related compounds in Pediococcus cerevisiae.

Authors:  F Mandelbaum-Shavit; N Grossowicz
Journal:  J Bacteriol       Date:  1970-10       Impact factor: 3.490

9.  Dihydrofolate reductase activity in strains of Streptococcus faecium var. durans resistant to methasquin and amethopterin.

Authors:  J I Rader; D J Hutchison
Journal:  J Bacteriol       Date:  1972-04       Impact factor: 3.490

10.  Dihydrofolate reductase of Streptococcus faicium. II. Purification and some properties of two dihydrofolate reductases from the amethopterin-resistant mutant Streptococcus faecium var. Durans strain A.

Authors:  P F Nixon; R L Blakley
Journal:  J Biol Chem       Date:  1968-09-25       Impact factor: 5.157
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  2 in total

1.  Physiological and enzymatic properties of a thymidine-requiring Pediococcus cerevisiae mutant.

Authors:  M Ariel; H Lavi; E Holtzer; N Grossowicz
Journal:  J Bacteriol       Date:  1982-05       Impact factor: 3.490

2.  Dihydrofolate reductases in some folate-requiring bacteria with low trimethoprim susceptibility.

Authors:  R L Then; H Riggenbach
Journal:  Antimicrob Agents Chemother       Date:  1978-07       Impact factor: 5.191
  2 in total

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