Literature DB >> 15830466

Synthesis and anticancer activity of new pyrrolocarbazoles and pyrrolo-beta-carbolines.

M Laronze1, M Boisbrun, S Léonce, B Pfeiffer, P Renard, O Lozach, L Meijer, A Lansiaux, C Bailly, J Sapi, J-Y Laronze.   

Abstract

'Bended' 1, 3 or 'linear' 2 pyrrolidino-fused (aza)carbazoles were prepared and screened towards a few cancer-related targets. Whereas 'bended' derivatives 1 and 3 proved to be weakly toxic, several members of the 'linear' family strongly interact with DNA, especially derivative 28a.

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Year:  2005        PMID： 15830466     DOI： 10.1016/j.bmc.2004.12.045

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  10 in total

1.  A spectroscopic study of the interaction of the fluorescent beta-carboline-3-carboxylic acid N-methylamide with DNA constituents: nucleobases, nucleosides and nucleotides.

Authors:  Iñigo X García-Zubiri; Hugh D Burrows; Joao S Seixas de Melo; María Monteserín; Antonio Arroyo; María J Tapia
Journal:  J Fluoresc       Date:  2008-05-11       Impact factor: 2.217

2.  Mechanism of AuCl₃-catalyzed cyclization of 1-(indol-2-yl)-3-alkyn-1-ols: a DFT study.

Authors:  Jingna Shao; Rongxing He; Wei Shen; Ming Li
Journal:  J Mol Model       Date:  2014-05-07       Impact factor: 1.810

Review 3.  Recent trends in targeted anticancer prodrug and conjugate design.

Authors:  Yashveer Singh; Matthew Palombo; Patrick J Sinko
Journal:  Curr Med Chem       Date:  2008       Impact factor: 4.530

4.  Three-step synthesis of an annulated β-carboline via palladium catalysis.

Authors:  Seann P Mulcahy; Jonathan G Varelas
Journal:  Tetrahedron Lett       Date:  2013-11-27       Impact factor: 2.415

5.  tert-Butyl 6-bromo-1,4-dimethyl-9H-carbazole-9-carboxyl-ate.

Authors:  Jean-François Lohier; Anna Caruso; Jana Sopková-de Oliveira Santos; Jean-Charles Lancelot; Sylvain Rault
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-07-10

6.  Synthesis of 3-(quinolin-2-yl)- and 3,6-bis(quinolin-2-yl)-9H-carbazoles.

Authors:  Yang Li; Wentao Gao
Journal:  Beilstein J Org Chem       Date:  2010-10-08       Impact factor: 2.883

7.  A novel and facile synthesis of 3-(2-benzofuroyl)- and 3,6-bis(2-benzofuroyl)carbazole derivatives.

Authors:  Wentao Gao; Meiru Zheng; Yang Li
Journal:  Beilstein J Org Chem       Date:  2011-11-17       Impact factor: 2.883

8.  Cytotoxic Effect of a Novel Synthesized Carbazole Compound on A549 Lung Cancer Cell Line.

Authors:  Refilwe P Molatlhegi; Alisa Phulukdaree; Krishnan Anand; Robert M Gengan; Charlette Tiloke; Anil A Chuturgoon
Journal:  PLoS One       Date:  2015-07-02       Impact factor: 3.240

9.  Small molecule PZL318: forming fluorescent nanoparticles capable of tracing their interactions with cancer cells and activated platelets, slowing tumor growth and inhibiting thrombosis.

Authors:  Shan Li; Yuji Wang; Feng Wang; Yaonan Wang; Xiaoyi Zhang; Ming Zhao; Qiqi Feng; Jianhui Wu; Shurui Zhao; Wei Wu; Shiqi Peng
Journal:  Int J Nanomedicine       Date:  2015-08-24

10.  XszenFHal, a novel tryptophan 5-halogenase from Xenorhabdus szentirmaii.

Authors:  Jérémy Domergue; Diane Erdmann; Aurélie Fossey-Jouenne; Jean-Louis Petit; Adrien Debard; Véronique de Berardinis; Carine Vergne-Vaxelaire; Anne Zaparucha
Journal:  AMB Express       Date:  2019-10-31       Impact factor: 3.298
  10 in total

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