| Literature DB >> 15829278 |
Elke Cario1, Daniel K Podolsky.
Abstract
This brief review summarizes the current understanding of Toll-like receptor (TLRs) mediated intestinal epithelial mechanisms of commensal tolerance versus intolerance and provides an update on the downstream negative control of signaling responses through decreased surface expression, interregulation with NOD2, overexpression of Tollip, various inhibitors of NF-kappaB as well as soluble tolerizing mediators present in lumen and serum which all may maintain or--when dysregulated--impair mucosal homeostasis in health or disease, respectively.Entities:
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Year: 2005 PMID： 15829278 DOI： 10.1016/j.molimm.2004.12.002
Source DB: PubMed Journal: Mol Immunol ISSN： 0161-5890 Impact factor: 4.407