| Literature DB >> 15828811 |
James T Anderson1, Anthony E Ting, Sherry Boozer, Kurt R Brunden, Joel Danzig, Tom Dent, John J Harrington, Steven M Murphy, Rob Perry, Amy Raber, Stephen E Rundlett, Jianmin Wang, Nancy Wang, Youssef L Bennani.
Abstract
Analogues of the natural product noscapine were synthesized, and their potential as antitumor agents were examined. The discovery of a novel regio- and stereoselective O-demethylation led to the synthesis of several O-alkylated analogues that induced an unexpected S-phase arrest of mammalian cells. Compound 4a was the most potent analogue inhibiting cell proliferation at an EC(50) of 1.9 microM.Entities:
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Year: 2005 PMID： 15828811 DOI： 10.1021/jm0494220
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446