Literature DB >> 15827841

How to appraise the effectiveness of treatment.

Mohit Bhandari1, R Brian Haynes.   

Abstract

Before implementing a new therapy, we should ascertain the benefits and risks of the therapy and assure ourselves that the resources consumed during the intervention will not be exorbitant. In the hierarchy of research designs, the results of randomized controlled trials, especially if systematically reviewed, are considered the highest level of evidence. We suggest a three-step approach to using an article from the medical literature to guide your patient care. We recommend that readers ask whether the study can provide valid results, review the results, and consider how the results can be applied to patient care. Given the time constraints of busy surgical practices and surgical training programs, applying this analysis to every relevant article will be challenging. However, the basis of this process is essentially what we all do many times each week when making decisions about whether and how to treat patients. Making this process explicit with guidelines to assess the strength of the available evidence can serve to improve patient care. It also allow us to defend therapeutic interventions based on available evidence and not anecdote.

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Year:  2005        PMID: 15827841     DOI: 10.1007/s00268-005-7915-9

Source DB:  PubMed          Journal:  World J Surg        ISSN: 0364-2313            Impact factor:   3.352


  18 in total

1.  The quality of reporting of randomized trials in the Journal of Bone and Joint Surgery from 1988 through 2000.

Authors:  Mohit Bhandari; Robin R Richards; Sheila Sprague; Emil H Schemitsch
Journal:  J Bone Joint Surg Am       Date:  2002-03       Impact factor: 5.284

2.  A consumer's guide to subgroup analyses.

Authors:  A D Oxman; G H Guyatt
Journal:  Ann Intern Med       Date:  1992-01-01       Impact factor: 25.391

3.  Does quality of reports of randomised trials affect estimates of intervention efficacy reported in meta-analyses?

Authors:  D Moher; B Pham; A Jones; D J Cook; A R Jadad; M Moher; P Tugwell; T P Klassen
Journal:  Lancet       Date:  1998-08-22       Impact factor: 79.321

4.  Physician interpretations and textbook definitions of blinding terminology in randomized controlled trials.

Authors:  P J Devereaux; B J Manns; W A Ghali; H Quan; C Lacchetti; V M Montori; M Bhandari; G H Guyatt
Journal:  JAMA       Date:  2001-04-18       Impact factor: 56.272

5.  Subgroup analysis and other (mis)uses of baseline data in clinical trials.

Authors:  S F Assmann; S J Pocock; L E Enos; L E Kasten
Journal:  Lancet       Date:  2000-03-25       Impact factor: 79.321

6.  Functional status changes following medical or surgical treatment for cerebral ischemia. Results of the extracranial-intracranial bypass study.

Authors:  R B Haynes; J Mukherjee; D L Sackett; D W Taylor; H J Barnett; S J Peerless
Journal:  JAMA       Date:  1987-04-17       Impact factor: 56.272

7.  When was a "negative" clinical trial big enough? How many patients you needed depends on what you found.

Authors:  A S Detsky; D L Sackett
Journal:  Arch Intern Med       Date:  1985-04

8.  Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials.

Authors:  K F Schulz; I Chalmers; R J Hayes; D G Altman
Journal:  JAMA       Date:  1995-02-01       Impact factor: 56.272

9.  Effect of encouragement on walking test performance.

Authors:  G H Guyatt; S O Pugsley; M J Sullivan; P J Thompson; L Berman; N L Jones; E L Fallen; D W Taylor
Journal:  Thorax       Date:  1984-11       Impact factor: 9.139

10.  Bias in treatment assignment in controlled clinical trials.

Authors:  T C Chalmers; P Celano; H S Sacks; H Smith
Journal:  N Engl J Med       Date:  1983-12-01       Impact factor: 91.245

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  3 in total

Review 1.  Combination pharmacotherapy for the treatment of neuropathic pain in adults.

Authors:  Luis Enrique Chaparro; Philip J Wiffen; R Andrew Moore; Ian Gilron
Journal:  Cochrane Database Syst Rev       Date:  2012-07-11

Review 2.  Pharmacotherapy for the prevention of chronic pain after surgery in adults.

Authors:  Luis Enrique Chaparro; Shane A Smith; R Andrew Moore; Philip J Wiffen; Ian Gilron
Journal:  Cochrane Database Syst Rev       Date:  2013-07-24

3.  APPLICABILITY OF RANDOMIZED TRIALS IN HAND SURGERY: SURVEY STUDY.

Authors:  Vinícius Ynoe DE Moraes; Priscila Frantz Ruff; Carlos Henrique Fernandes; João Baptista Gomes Dos Santos; João Carlos Belloti; Flávio Faloppa
Journal:  Acta Ortop Bras       Date:  2018 May-Jun       Impact factor: 0.513

  3 in total

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