CONTEXT: Epidemiological data suggest that high calcium intakes are associated with decreased body weight and blood pressure. However, there is little evidence from randomized trials that addresses these important issues. OBJECTIVE: The objective of this study was to assess the long-term effects of calcium on body weight and blood pressure. DESIGN: This is a substudy of an ongoing, double-blind, randomized, controlled trial of calcium supplementation. End points were assessed at 30 months. SETTING: This study was performed at a university medical center. PARTICIPANTS: Normal postmenopausal women (mean age, 74 yr; mean weight, 67 kg; mean blood pressure, 134/70 mm Hg at baseline) participated in this study. INTERVENTION: Study subjects were treated with calcium (1 g/d; n = 732) and placebo (n = 739). MAIN OUTCOME MEASURES: Body weight and blood pressure were the main outcome measures. RESULTS:Weight decreased by 368 +/- 132 g (mean +/- se) with calcium treatment and by 369 +/- 134 g with placebo (P = 0.93). Fat and lean masses did not show an effect of calcium. Blood pressure showed transient reductions of 1-2 mm Hg at 6 months in the calcium group, resulting in a significant between-group difference only for systolic pressure (P = 0.048). At 30 months, the change from baseline in systolic pressure was 0.0 +/- 0.9 mm Hg in the calcium group and 2.4 +/- 0.9 mm Hg in the placebo group (P = 0.14). For diastolic pressures, the changes were -0.2 +/- 0.4 and 0.8 +/- 0.4 mm Hg, respectively (P = 0.13). In those with baseline calcium intakes less than 600 mg/d, the treatment effect was greater and did persist. CONCLUSIONS:Calcium supplementation of 1 g/d does not produce biologically significant effects on body weight, and its hypotensive effect is small and transient in most women.
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CONTEXT: Epidemiological data suggest that high calcium intakes are associated with decreased body weight and blood pressure. However, there is little evidence from randomized trials that addresses these important issues. OBJECTIVE: The objective of this study was to assess the long-term effects of calcium on body weight and blood pressure. DESIGN: This is a substudy of an ongoing, double-blind, randomized, controlled trial of calcium supplementation. End points were assessed at 30 months. SETTING: This study was performed at a university medical center. PARTICIPANTS: Normal postmenopausal women (mean age, 74 yr; mean weight, 67 kg; mean blood pressure, 134/70 mm Hg at baseline) participated in this study. INTERVENTION: Study subjects were treated with calcium (1 g/d; n = 732) and placebo (n = 739). MAIN OUTCOME MEASURES: Body weight and blood pressure were the main outcome measures. RESULTS: Weight decreased by 368 +/- 132 g (mean +/- se) with calcium treatment and by 369 +/- 134 g with placebo (P = 0.93). Fat and lean masses did not show an effect of calcium. Blood pressure showed transient reductions of 1-2 mm Hg at 6 months in the calcium group, resulting in a significant between-group difference only for systolic pressure (P = 0.048). At 30 months, the change from baseline in systolic pressure was 0.0 +/- 0.9 mm Hg in the calcium group and 2.4 +/- 0.9 mm Hg in the placebo group (P = 0.14). For diastolic pressures, the changes were -0.2 +/- 0.4 and 0.8 +/- 0.4 mm Hg, respectively (P = 0.13). In those with baseline calcium intakes less than 600 mg/d, the treatment effect was greater and did persist. CONCLUSIONS:Calcium supplementation of 1 g/d does not produce biologically significant effects on body weight, and its hypotensive effect is small and transient in most women.
Authors: E O Billington; S M Bristow; G D Gamble; J A de Kwant; A Stewart; B V Mihov; A M Horne; I R Reid Journal: Osteoporos Int Date: 2016-08-20 Impact factor: 4.507
Authors: Mark J Bolland; P Alan Barber; Robert N Doughty; Barbara Mason; Anne Horne; Ruth Ames; Gregory D Gamble; Andrew Grey; Ian R Reid Journal: BMJ Date: 2008-01-15
Authors: Jack A Yanovski; Shamik J Parikh; Lisa B Yanoff; Blakeley I Denkinger; Karim A Calis; James C Reynolds; Nancy G Sebring; Teresa McHugh Journal: Ann Intern Med Date: 2009-06-16 Impact factor: 25.391