| Literature DB >> 15827015 |
Stefan Glasauer1, Michael Strupp, Roger Kalla, Ulrich Büttner, Thomas Brandt.
Abstract
The potassium channel blocker 4-aminopyridine (4-AP) restored vertical smooth pursuit and gaze holding in light in one patient with upbeat (UBN) and in one with downbeat nystagmus (DBN). Without a visible target, however, 4-AP had no effect on UBN, but DBN vanished. We hypothesize that this difference in the effects of 4-AP, which is known to increase the excitability of cerebellar Purkinje cells, can be attributed to the different lesion sites involved in UBN and DBN.Entities:
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Year: 2005 PMID： 15827015 DOI： 10.1196/annals.1325.060
Source DB: PubMed Journal: Ann N Y Acad Sci ISSN： 0077-8923 Impact factor: 5.691