| Literature DB >> 1582645 |
J Daigneault1, G Aubin, F Simard, M De Braekeleer.
Abstract
The incidence of cystic fibrosis (CF) in Saguenay-Lac-St.-Jean, a geographically isolated region of Quebec, was estimated to be 1 in 902 during the period 1975-1988. The carrier rate was calculated to be 1 in 15 inhabitants. The high incidence of CF in Saguenay-Lac-St.-Jean is probably the result of a founder effect and genetic drift for one or more mutations. Historical, demographic, and social factors also may have contributed to the high incidence.Entities:
Mesh：
Year: 1992 PMID： 1582645
Source DB: PubMed Journal: Hum Biol ISSN： 0018-7143 Impact factor: 0.553