Literature DB >> 15825421

Chemotherapy of an experimental Fusobacterium (Sphaerophorus) necrophorum infection in mice.

T D Wilkins, L D Smith.   

Abstract

An experimental animal model for testing antibiotics in vivo against Fusobacterium (Sphaerophorus) necrophorum has been developed. It incorporates the subcutaneous injection of the bacteria into mice followed by intraperitoneal administration of the antibiotic at 24, 48, 72, and 96 h. Mean effective dose values are based on the number of survivors 21 days after challenge. Tetracycline was the most effective drug tested, with a mean effective dose of 5.0 mg/kg, compared with mean effective dose values of 11.1 for clindamycin, 11.8 for penicillin-G, and 52.9 for lincomycin.

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Year:  1974        PMID： 15825421      PMCID： PMC429030          DOI： 10.1128/AAC.5.6.658

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  10 in total

1.  The effect of chlortetracycline, fed continuously during fattening, on the incidence of liver abscesses in beef cattle.

Authors:  J C FLINT; R JENSEN
Journal:  Am J Vet Res       Date:  1958-10       Impact factor: 1.156

2.  The Isolation of L Type Cultures from Bacteroides with the Aid of Penicillin and Their Reversion into the Usual Bacilli.

Authors:  L Dienes
Journal:  J Bacteriol       Date:  1948-10       Impact factor: 3.490

3.  L-Type Variation and Bacterial Reproduction by Large Bodies as Seen in Electron Micrographic Studies of Bacteroides funduliformis.

Authors:  W E Smith; S Mudd; J Hillier
Journal:  J Bacteriol       Date:  1948-11       Impact factor: 3.490

4.  Treatment of anaerobic infections with lincomycin and clindamycin.

Authors:  J G Bartlett; V L Sutter; S M Finegold
Journal:  N Engl J Med       Date:  1972-11-16       Impact factor: 91.245

5.  Clindamycin in the treatment of serious anaerobic infections.

Authors:  R J Fass; J F Scholand; G R Hodges; S Saslaw
Journal:  Ann Intern Med       Date:  1973-06       Impact factor: 25.391

6.  Standardized single-disc method for antibiotic susceptibility testing of anaerobic bacteria.

Authors:  T D Wikins; L V Holdeman; I J Abramson; W E Moore
Journal:  Antimicrob Agents Chemother       Date:  1972-06       Impact factor: 5.191

7.  "Bacteroides" bacteremia.

Authors:  J M Felner; V R Dowell
Journal:  Am J Med       Date:  1971-06       Impact factor: 4.965

8.  Clinical investigations of infectious foot rot of cattle.

Authors:  D W Johnson; A R Dommert; D G Kiger
Journal:  J Am Vet Med Assoc       Date:  1969-12-15       Impact factor: 1.936

9.  Phosphonomycin. V. Evaluation in mice.

Authors:  A K Miller; B M Frost; M E Valiant; H Kropp; D Hendlin
Journal:  Antimicrob Agents Chemother (Bethesda)       Date:  1969

10.  Treatment of severe bacteroides infections with parenteral clindamycin.

Authors:  E V Haldane; C E Van Rooyen
Journal:  Can Med Assoc J       Date:  1972-12-23       Impact factor: 8.262
  10 in total
  12 in total

1.  Effects of minocycline and other antibiotics on Fusobacterium necrophorum infections in mice.

Authors:  N A Kuck
Journal:  Antimicrob Agents Chemother       Date:  1975-04       Impact factor: 5.191

Review 2.  Fusobacterium necrophorum: its characteristics and role as an animal pathogen.

Authors:  B F Langworth
Journal:  Bacteriol Rev       Date:  1977-06

3.  The pathogenic properties of Fusobacterium and Bacteroides species from wallabies and other sources.

Authors:  G R Smith; J C Oliphant; R Parsons
Journal:  J Hyg (Lond)       Date:  1984-04

4.  Anaerobic orbital cellulitis: a clinical and experimental study.

Authors:  M S Jedrzynski; J D Bullock; T W McGuire; B L Elder; J D Bullock
Journal:  Trans Am Ophthalmol Soc       Date:  1991

5.  Comparison of cefoxitin and cephalothin therapy of a mixed Bacteroides fragilis and Fusobacterius necrophorum infection in mice.

Authors:  A S Hackman; T D Wilkins
Journal:  Antimicrob Agents Chemother       Date:  1975-08       Impact factor: 5.191

6.  Evaluation of experimentally induced Fusobacterium necrophorum infections in mice.

Authors:  P J Conlon; K P Hepper; G W Teresa
Journal:  Infect Immun       Date:  1977-02       Impact factor: 3.441

7.  Fusobacterium necrophorum infection in mice as a model for the study of liver abscess formation and induction of immunity.

Authors:  P M Abe; E S Lennard; J W Holland
Journal:  Infect Immun       Date:  1976-05       Impact factor: 3.441

8.  In vivo protection of Fusobacterium necrophorum from penicillin by Bacteroides fragilis.

Authors:  A S Hackman; T D Wilkins
Journal:  Antimicrob Agents Chemother       Date:  1975-05       Impact factor: 5.191

9.  Pharmacokinetic and in vivo studies with azithromycin (CP-62,993), a new macrolide with an extended half-life and excellent tissue distribution.

Authors:  A E Girard; D Girard; A R English; T D Gootz; C R Cimochowski; J A Faiella; S L Haskell; J A Retsema
Journal:  Antimicrob Agents Chemother       Date:  1987-12       Impact factor: 5.191

10.  Animal model for anaerobic lung abscess.

Authors:  D W Kannangara; H Thadepalli; V T Bach; D Webb
Journal:  Infect Immun       Date:  1981-02       Impact factor: 3.441
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