Literature DB >> 15825304

Evaluation of the efficacy of minocycline therapy for staphylococcal soft-tissue infection.

J P Phair, R E Hartman, J Carleton.   

Abstract

Ten patients with soft-tissue infections due to Staphylococcus aureus were treated with minocycline, a semisynthetic tetracycline with potent in vitro antistaphylococcal effects. Serum concentrations averaged three to five times the concentration of minocycline required to inhibit growth of S. aureus in vitro. Clearing of the infecting organism was slow (less than 50% of lesions were sterile on day 10 of therapy), but clinical improvement was noted in 8 of 10 patients.

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Year:  1974        PMID： 15825304      PMCID： PMC444691          DOI： 10.1128/AAC.6.5.551

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  10 in total

1.  SIMPLE METHOD FOR PHAGE TYPING OF STAPHYLOCOCCI.

Authors:  H J SIMON; S UNDSETH
Journal:  J Bacteriol       Date:  1963-06       Impact factor: 3.490

2.  Single-disk antibiotic-sensitivity testing of staphylococci; an analysis of technique and results.

Authors:  A W BAUER; D M PERRY; W M KIRBY
Journal:  AMA Arch Intern Med       Date:  1959-08

3.  The techniques and interpretation of phage typing of staphylococci.

Authors:  J E BLAIR; M CARR
Journal:  J Lab Clin Med       Date:  1960-04

4.  Susceptibility of common pathogenic bacteria to seven tetracycline antibiotics in vitro.

Authors:  N H Steigbigel; C W Reed; M Finland
Journal:  Am J Med Sci       Date:  1968-03       Impact factor: 2.378

5.  Pharmacokinetic studies on minocycline in man.

Authors:  H Macdonald; R G Kelly; E S Allen; J F Noble; L A Kanegis
Journal:  Clin Pharmacol Ther       Date:  1973 Sep-Oct       Impact factor: 6.875

6.  Simplified, accurate method for antibiotic assay of clinical specimens.

Authors:  J V Bennett; J L Brodie; E J Benner; W M Kirby
Journal:  Appl Microbiol       Date:  1966-03

7.  The slow bactericidal effect of tetracycline and minocycline on wall-defective staphylococcus.

Authors:  J Carleton; J P Phair
Journal:  J Infect Dis       Date:  1972-10       Impact factor: 5.226

8.  Bacteriologic and clinical evaluation of minocycline, a new tetracycline.

Authors:  R Cappel; J Klastersky
Journal:  Curr Ther Res Clin Exp       Date:  1971-04

9.  Susceptibility of Staphylococci to Minocycline In Vitro: Identification of Group III Bacteriophage Types by Characteristic Inhibition of Growth.

Authors:  J P Phair; J Carleton
Journal:  Infect Immun       Date:  1970-11       Impact factor: 3.441

10.  Uptake of minocycline and tetracycline by tetracycline-susceptible and -resistant bacteria.

Authors:  N A Kuck; M Forbes
Journal:  Antimicrob Agents Chemother       Date:  1973-06       Impact factor: 5.191
  10 in total
  2 in total

1.  Combination of minocycline and rifampicin against methicillin- and gentamicin-resistant Staphylococcus aureus.

Authors:  E Yourassowsky; M P van der Linden; M J Lismont; F Crokaert
Journal:  J Clin Pathol       Date:  1981-05       Impact factor: 3.411

Review 2.  Minocycline as A Substitute for Doxycycline in Targeted Scenarios: A Systematic Review.

Authors:  Nicholas W Carris; Joe Pardo; Jose Montero; Kristy M Shaeer
Journal:  Open Forum Infect Dis       Date:  2015-11-25       Impact factor: 3.835
  2 in total

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