Literature DB >> 15824036

Manufacturing techniques of biodegradable implants intended for intraocular application.

Sílvia Ligório Fialho1, Armando da Silva Cunha.   

Abstract

Polylactic acid and polylactic-co-glycolic acid are biocompatible and biodegradable polymers with wide utility for the design of controlled release systems for drugs. Regarding intraocular application, polymeric sustained-drug release systems are being studied to treat vitreoretinal diseases. Our work aimed to compare the influence of two implant manufacturing techniques, compression and hot molding, on the in vitro degradation of the polymeric matrices and on the release of dexamethasone acetate. The results showed that the manufacturing technique highly influences degradation and drug release processes. The compressed systems degraded faster and allowed one faster release of the drug.

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Year:  2005        PMID： 15824036     DOI： 10.1080/10717540590921432

Source DB:  PubMed          Journal:  Drug Deliv        ISSN： 1071-7544            Impact factor:   6.419


  7 in total

1.  Anti-Toxoplasma activity and impact evaluation of lyophilization, hot molding process, and gamma-irradiation techniques on CLH-PLGA intravitreal implants.

Authors:  Gabriella M Fernandes-Cunha; Cíntia M F Rezende; Wagner N Mussel; Gisele R da Silva; Elionai C de L Gomes; Maria I Yoshida; Sílvia L Fialho; Alfredo M Goes; Dawison A Gomes; Ricardo W de Almeida Vitor; Armando Silva-Cunha
Journal:  J Mater Sci Mater Med       Date:  2015-12-16       Impact factor: 3.896

2.  Antiangiogenic activity of PLGA-Lupeol implants for potential intravitreal applications.

Authors:  Daniel Crístian Ferreira Soares; Diogo Coelho de Paula Oliveira; Luciola Silva Barcelos; Alan Sales Barbosa; Lorena Carla Vieira; Danyelle M Townsend; Domenico Rubello; André Luis Branco de Barros; Lucienir Pains Duarte; Armando Silva-Cunha
Journal:  Biomed Pharmacother       Date:  2017-05-27       Impact factor: 6.529

3.  Ocular safety of Intravitreal Clindamycin Hydrochloride Released by PLGA Implants.

Authors:  Gabriella M Fernandes-Cunha; Silvia Ligório Fialho; Gisele Rodrigues da Silva; Armando Silva-Cunha; Min Zhao; Francine Behar-Cohen
Journal:  Pharm Res       Date:  2017-02-21       Impact factor: 4.200

4.  Development of a Biodegradable Subcutaneous Implant for Prolonged Drug Delivery Using 3D Printing.

Authors:  Sarah A Stewart; Juan Domínguez-Robles; Victoria J McIlorum; Elena Mancuso; Dimitrios A Lamprou; Ryan F Donnelly; Eneko Larrañeta
Journal:  Pharmaceutics       Date:  2020-01-28       Impact factor: 6.321

5.  Thermoanalytical characterization of clindamycin-loaded intravitreal implants prepared by hot melt extrusion.

Authors:  Lana Tamaddon; Seyed Abolfazl Mostafavi; Reza Karkhane; Mohammad Riazi-Esfahani; Farid Abedin Dorkoosh; Morteza Rafiee-Tehrani
Journal:  Adv Biomed Res       Date:  2015-07-27

6.  Poly(caprolactone)-Based Coatings on 3D-Printed Biodegradable Implants: A Novel Strategy to Prolong Delivery of Hydrophilic Drugs.

Authors:  Sarah A Stewart; Juan Domínguez-Robles; Victoria J McIlorum; Zoilo Gonzalez; Emilia Utomo; Elena Mancuso; Dimitrios A Lamprou; Ryan F Donnelly; Eneko Larrañeta
Journal:  Mol Pharm       Date:  2020-08-03       Impact factor: 4.939

7.  Assessing the maxillary sinus mucosa of rabbits in the presence of biodegradable implants.

Authors:  André Coura Perez; Armando da Silva Cunha Junior; Sílvia Ligório Fialho; Lívia Mara Silva; João Vicente Dorgam; Adriana de Andrade Batista Murashima; Alfredo Ribeiro Silva; Maria Rossato; Wilma Terezinha Anselmo-Lima
Journal:  Braz J Otorhinolaryngol       Date:  2012-12
  7 in total

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