Literature DB >> 15822988

Ionic-liquid-supported peptide synthesis demonstrated by the synthesis of Leu(5)-enkephalin.

Weishi Miao1, Tak-Hang Chan.   

Abstract

A new strategy for the synthesis of oligopeptides was developed using an ionic liquid as a soluble support. The efficiency of this ionic liquid-phase approach was demonstrated by the synthesis of a bioactive pentapeptide, Leu(5)-enkephalin, in good yield and reasonable purity. The structures and purities of the reaction intermediates in each step were verified easily by routine spectroscopic analysis, and no chromatographic procedures were needed during the synthesis.

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Year:  2005        PMID： 15822988     DOI： 10.1021/jo050006c

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  5 in total

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Authors:  Shaokun Tang; Gary A Baker; Hua Zhao
Journal:  Chem Soc Rev       Date:  2012-03-28       Impact factor: 54.564

2.  Electrospray mass spectral fragmentation study of N,N'-disubstituted imidazolium ionic liquids.

Authors:  Alain Lesimple; Orval Mamer; Weishi Miao; Tak Hang Chan
Journal:  J Am Soc Mass Spectrom       Date:  2005-12-15       Impact factor: 3.109

3.  Imidazolium cation supported solution-phase assembly of homolinear alpha(1-->6)-linked octamannoside: an efficient alternate approach for oligosaccharide synthesis.

Authors:  Charu K Yerneni; Vibha Pathak; Ashish K Pathak
Journal:  J Org Chem       Date:  2009-08-21       Impact factor: 4.354

Review 4.  Ionic liquid applications in peptide chemistry: synthesis, purification and analytical characterization processes.

Authors:  Alesia A Tietze; Pascal Heimer; Annegret Stark; Diana Imhof
Journal:  Molecules       Date:  2012-04-05       Impact factor: 4.411

5.  tert-Butyloxycarbonyl-protected amino acid ionic liquids and their application to dipeptide synthesis.

Authors:  Ming Chen; Xihan Yu
Journal:  RSC Adv       Date:  2021-08-13       Impact factor: 4.036
  5 in total

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