Literature DB >> 1582256

Regional mapping of the gene for autosomal dominant spinocerebellar ataxia (SCA1) by localizing the closely linked D6S89 locus to 6p24.2----p23.05.

A Volz1, C Fonatsch, A Ziegler.   

Abstract

The locus for one subtype of autosomal dominant spinocerebellar ataxias (SCA1) is closely linked (within 1-2 cM) to D6S89, which contains a highly polymorphic dinucleotide repeat sequence. D6S89 has been mapped previously to 6p24----p21.3, between the HLA and F13A1 loci. Mutant cell lines were used to correlate the absence or presence of D6S89 with cytogenetically detectable interstitial 6p deletions. The results allowed us to map D6S89 to the 6p24.2----p23.05 region. The close linkage of SCA1 to D6S89 indicates that this locus is most likely located in the 6p24----p23 segment.

Entities:  

Mesh：

Substances：

Year:  1992        PMID： 1582256     DOI： 10.1159/000133291

Source DB:  PubMed          Journal:  Cytogenet Cell Genet        ISSN： 0301-0171


  6 in total

1.  Presence of an expressed beta-tubulin gene (TUBB) in the HLA class I region may provide the genetic basis for HLA-linked microtubule dysfunction.

Authors:  A Volz; E Weiss; J Trowsdale; A Ziegler
Journal:  Hum Genet       Date:  1994-01       Impact factor: 4.132

2.  Exclusion of ferritins and iron-responsive element (IRE)-binding proteins as candidates for the hemochromatosis gene.

Authors:  H Zheng; D Bhavsar; A Volz; A Ziegler; J Drysdale
Journal:  Hum Genet       Date:  1994-08       Impact factor: 4.132

3.  MHC-linked olfactory receptor loci exhibit polymorphism and contribute to extended HLA/OR-haplotypes.

Authors:  A Ehlers; S Beck; S A Forbes; J Trowsdale; A Volz; R Younger; A Ziegler
Journal:  Genome Res       Date:  2000-12       Impact factor: 9.043

4.  Spinocerebellar ataxia 1 (SCA1) in the Japanese in Hokkaido may derive from a single common ancestry.

Authors:  A Wakisaka; H Sasaki; A Takada; T Fukazawa; Y Suzuki; T Hamada; K Iwabuchi; K Tashiro; T Yoshiki
Journal:  J Med Genet       Date:  1995-08       Impact factor: 6.318

5.  A subset of HLA-B27 molecules contains peptides much longer than nonamers.

Authors:  R G Urban; R M Chicz; W S Lane; J L Strominger; A Rehm; M J Kenter; F G UytdeHaag; H Ploegh; B Uchanska-Ziegler; A Ziegler
Journal:  Proc Natl Acad Sci U S A       Date:  1994-02-15       Impact factor: 11.205

6.  The gene for spinal cerebellar ataxia 3 (SCA3) is located in a region of approximately 3 cM on chromosome 14q24.3-q32.2.

Authors:  G Stevanin; G Cancel; A Dürr; H Chneiweiss; O Dubourg; J Weissenbach; H M Cann; Y Agid; A Brice
Journal:  Am J Hum Genet       Date:  1995-01       Impact factor: 11.025
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.