BACKGROUND & AIMS: The role of desmoplasia in colorectal carcinoma progression is unclear and the presence of collagen stroma may represent a barrier against cancer diffusion and vascular invasion or a stroma to build up and support the tumor. The aim of this study was to evaluate the effect of desmoplastic response on long-term survival of patients who underwent radical resection for colorectal carcinoma. METHODS: The study included 429 patients who underwent radical colorectal resection for cancer with a median follow-up period of 72.8 months. RESULTS: At univariate analysis significant associations were observed between desmoplasia and histologic type, parietal infiltration, growth pattern, and staging. No associations were found between desmoplasia and the other clinical and histologic parameters. The multivariate analysis stratified for tumor stage revealed that the factor showing the most favorable influence on time to death was desmoplasia. The presence of desmoplasia was likely to decrease the failure rate to a third of the rate experienced by patients without desmoplasia. Parietal infiltration was associated with an increased risk for a shortened time to death. CONCLUSIONS: Our results favor the view that desmoplasia is a protective factor for survival in patients with colorectal carcinoma. This finding is consistent with the hypothesis that desmoplasia may prevent cancer invasiveness by building a barrier against tumor diffusion.
BACKGROUND & AIMS: The role of desmoplasia in colorectal carcinoma progression is unclear and the presence of collagen stroma may represent a barrier against cancer diffusion and vascular invasion or a stroma to build up and support the tumor. The aim of this study was to evaluate the effect of desmoplastic response on long-term survival of patients who underwent radical resection for colorectal carcinoma. METHODS: The study included 429 patients who underwent radical colorectal resection for cancer with a median follow-up period of 72.8 months. RESULTS: At univariate analysis significant associations were observed between desmoplasia and histologic type, parietal infiltration, growth pattern, and staging. No associations were found between desmoplasia and the other clinical and histologic parameters. The multivariate analysis stratified for tumor stage revealed that the factor showing the most favorable influence on time to death was desmoplasia. The presence of desmoplasia was likely to decrease the failure rate to a third of the rate experienced by patients without desmoplasia. Parietal infiltration was associated with an increased risk for a shortened time to death. CONCLUSIONS: Our results favor the view that desmoplasia is a protective factor for survival in patients with colorectal carcinoma. This finding is consistent with the hypothesis that desmoplasia may prevent cancer invasiveness by building a barrier against tumor diffusion.
Authors: Kristina A Trujillo; Christopher M Heaphy; Minh Mai; Keith M Vargas; Anna C Jones; Phung Vo; Kimberly S Butler; Nancy E Joste; Marco Bisoffi; Jeffrey K Griffith Journal: Int J Cancer Date: 2011-02-11 Impact factor: 7.396
Authors: Sam Ghazi; Susanna von Holst; Simone Picelli; Ulrik Lindforss; Albert Tenesa; Susan M Farrington; Harry Campbell; Malcolm G Dunlop; Nikos Papadogiannakis; Annika Lindblom Journal: Am J Pathol Date: 2010-12 Impact factor: 4.307
Authors: Maddalena Zippi; Giorgio De Toma; Giovanni Minervini; Claudio Cassieri; Roberta Pica; Diodoro Colarusso; Simon Stock; Pietro Crispino Journal: Saudi J Gastroenterol Date: 2017 Jan-Feb Impact factor: 2.485
Authors: Neel I Nissen; Stephanie Kehlet; Mogens K Boisen; Maria Liljefors; Christina Jensen; Astrid Z Johansen; Julia S Johansen; Janine T Erler; Morten Karsdal; Joachim H Mortensen; Anette Høye; Nicholas Willumsen Journal: Sci Rep Date: 2021-01-13 Impact factor: 4.379