[Dynamics of postinfarction left ventricular remodeling during long term use of perindopril, amiodarone, and beta-adrenoblockers].

Perindopril was used in 287 patients with left ventricular ejection fraction < or =40% for 1 year after myocardial infarction either alone (n=53), or in combination with amiodarone (n=53), metoprolol (n=32), bisoprolol (n=32), carvedilol (n=32), atenolol (n=32), amiodarone and carvedilol (n=53). According to echocardiography data the use of combination of perindopril with metoprolol and especially carvedilol but not with amiodarone, bisoprolol, or atenolol, was associated with augmented anti-remodeling effect. The use of metoprolol, bisoprolol, and carvedilol but not of atenolol was associated with improvement of left ventricular systolic function. Amiodarone, metoprolol, bisoprolol, and atenolol, but not carvedilol diminished beneficial effect of perindopril on left ventricular diastolic function. The use of combination of perindopril with amiodarone or carvedilol was associated with less pronounced remodeling and most rapid and substantial improvement of left ventricular systolic and diastolic function.

RCT Entities:   Population Interventions Outcomes