Literature DB >> 15820766

Purification of cyclotron-produced 203Pb for labeling Herceptin.

Kayhan Garmestani1, Diane E Milenic, Erik D Brady, Paul S Plascjak, Martin W Brechbiel.   

Abstract

A simple and rapid procedure was developed for the purification of cyclotron-produced 203Pb via the 203Tl(d,2n) 203Pb reaction. A Pb(II) selective ion-exchange resin, with commercial name Pb Resin from Eichrom Technologies, Inc., was used to purify 203Pb from the cyclotron-irradiated Tl target with excellent recovery of the enriched Tl target material. The purified 203Pb was used to radiolabel the monoclonal antibody Herceptin. The in vitro and in vivo properties of the 203Pb radioimmunoconjugate were evaluated.

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Year:  2005        PMID： 15820766     DOI： 10.1016/j.nucmedbio.2004.11.004

Source DB:  PubMed          Journal:  Nucl Med Biol        ISSN： 0969-8051            Impact factor:   2.408


  8 in total

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Journal:  Cancer Biother Radiopharm       Date:  2018-06       Impact factor: 3.099

2.  Evaluation of a Novel Pb-203-Labeled Lactam-Cyclized Alpha-Melanocyte-Stimulating Hormone Peptide for Melanoma Targeting.

Authors:  Jianquan Yang; Jingli Xu; Lina Cheuy; Rene Gonzalez; Darrell R Fisher; Yubin Miao
Journal:  Mol Pharm       Date:  2019-02-25       Impact factor: 4.939

3.  Towards translation of 212Pb as a clinical therapeutic; getting the lead in!

Authors:  Kwon Yong; Martin W Brechbiel
Journal:  Dalton Trans       Date:  2011-03-04       Impact factor: 4.390

4.  203Pb-labeled alpha-melanocyte-stimulating hormone peptide as an imaging probe for melanoma detection.

Authors:  Yubin Miao; Said D Figueroa; Darrell R Fisher; Herbert A Moore; Richard F Testa; Timothy J Hoffman; Thomas P Quinn
Journal:  J Nucl Med       Date:  2008-04-15       Impact factor: 10.057

5.  Synthesis and characterization of αvβ₃-targeting peptidomimetic chelate conjugates for PET and SPECT imaging.

Authors:  Young-Seung Kim; Kido Nwe; Diane E Milenic; Martin W Brechbiel; Stanley Satz; Kwamena E Baidoo
Journal:  Bioorg Med Chem Lett       Date:  2012-07-14       Impact factor: 2.823

6.  Preclinical Evaluation of 203/212Pb-Labeled Low-Molecular-Weight Compounds for Targeted Radiopharmaceutical Therapy of Prostate Cancer.

Authors:  Sangeeta Ray Banerjee; Il Minn; Vivek Kumar; Anders Josefsson; Ala Lisok; Mary Brummet; Jian Chen; Ana P Kiess; Kwamena Baidoo; Cory Brayton; Ronnie C Mease; Martin Brechbiel; George Sgouros; Robert F Hobbs; Martin G Pomper
Journal:  J Nucl Med       Date:  2019-06-28       Impact factor: 11.082

7.  Production, purification, and radiolabeling of the 203Pb/212Pb theranostic pair.

Authors:  Brooke L McNeil; Andrew K H Robertson; Winnie Fu; Hua Yang; Cornelia Hoehr; Caterina F Ramogida; Paul Schaffer
Journal:  EJNMMI Radiopharm Chem       Date:  2021-02-01

8.  Bench to Bedside: Stability Studies of GMP Produced Trastuzumab-TCMC in Support of a Clinical Trial.

Authors:  Diane E Milenic; Kwamena E Baidoo; Martin W Brechbiel
Journal:  Pharmaceuticals (Basel)       Date:  2015-07-29
  8 in total

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