| Literature DB >> 15820671 |
Abstract
Effects of the cytokine TGF-beta can be dampened by E3 ubiquitin ligases that target specific Smads, the TGF-beta signal transducers, for proteolytic destruction. Two papers in this issue of Cell highlight the importance of this mechanism in regulating the in vivo effects of TGF-beta. The first paper identifies and characterizes a novel Smad4 ubiquitin ligase, and the second paper redefines the role of a previously identified Smad1 ubiquitin ligase, Smurf-1 (Dupont et al., 2005; Yamashita et al., 2005).Entities:
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Year: 2005 PMID： 15820671 DOI： 10.1016/j.cell.2005.03.017
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582