BACKGROUND: Attentional control of executive cognitive function (ECF) decreases in older individuals with Alzheimer Disease (AD). In order to examine early AD-related changes in the neural substrates of ECF attentional control, we measured activation dorsolateral prefrontal (dLPFC), posterior parietal (PPC), and anterior cingulate cortex (ACC) in adults with mild cognitively impairment (MCI) and in cognitively normal (CN) adults. METHODS: Functional magnetic resonance imaging analysis of brain activation in MCI (n = 8, mean age 79.5) and CN (n = 8 mean age 81.5) during increasing loads of attentional demands. RESULTS: MCI and CN older adults performed with similar accuracy and reaction time. MCI had greater activation than CN in PPC (right p = .03 and left p = .05) and dlPFC areas (right p = .002 and left p = .004), while activation in ACC was similar in the two groups. Response to increasing loads of the task differed by group: MCI selectively engaged bilateral PPC (right p = .03, left p = .04), while CN subjects increased bilateral dlPFC activation (right p = .005 and left p = .02) and ACC activation (p = .04). Among MCI, greater load-related changes in PPC activity were associated with smaller load-related changes in accuracy rates (r = -.85, p = .07) and greater increases in reaction times (r = .97, p = .01). In CN subjects, load-related change in PPC activation was associated with load-related change in reaction time (r = .76, p = .02) but not with changes in accuracy rates. CONCLUSIONS: PPC and dlPFC may show early functional changes associated with MCI.
BACKGROUND: Attentional control of executive cognitive function (ECF) decreases in older individuals with Alzheimer Disease (AD). In order to examine early AD-related changes in the neural substrates of ECF attentional control, we measured activation dorsolateral prefrontal (dLPFC), posterior parietal (PPC), and anterior cingulate cortex (ACC) in adults with mild cognitively impairment (MCI) and in cognitively normal (CN) adults. METHODS: Functional magnetic resonance imaging analysis of brain activation in MCI (n = 8, mean age 79.5) and CN (n = 8 mean age 81.5) during increasing loads of attentional demands. RESULTS: MCI and CN older adults performed with similar accuracy and reaction time. MCI had greater activation than CN in PPC (right p = .03 and left p = .05) and dlPFC areas (right p = .002 and left p = .004), while activation in ACC was similar in the two groups. Response to increasing loads of the task differed by group: MCI selectively engaged bilateral PPC (right p = .03, left p = .04), while CN subjects increased bilateral dlPFC activation (right p = .005 and left p = .02) and ACC activation (p = .04). Among MCI, greater load-related changes in PPC activity were associated with smaller load-related changes in accuracy rates (r = -.85, p = .07) and greater increases in reaction times (r = .97, p = .01). In CN subjects, load-related change in PPC activation was associated with load-related change in reaction time (r = .76, p = .02) but not with changes in accuracy rates. CONCLUSIONS: PPC and dlPFC may show early functional changes associated with MCI.
Authors: Cheryl L Grady; Anthony R McIntosh; Sania Beig; Michelle L Keightley; Hana Burian; Sandra E Black Journal: J Neurosci Date: 2003-02-01 Impact factor: 6.167
Authors: Oscar L Lopez; William J Jagust; Corinne Dulberg; James T Becker; Steven T DeKosky; Annette Fitzpatrick; John Breitner; Constantine Lyketsos; Beverly Jones; Claudia Kawas; Michelle Carlson; Lewis H Kuller Journal: Arch Neurol Date: 2003-10
Authors: Oscar L Lopez; William J Jagust; Steven T DeKosky; James T Becker; Annette Fitzpatrick; Corinne Dulberg; John Breitner; Constantine Lyketsos; Beverly Jones; Claudia Kawas; Michelle Carlson; Lewis H Kuller Journal: Arch Neurol Date: 2003-10
Authors: Marta Encinas; Ramón De Juan; Alberto Marcos; Pedro Gil; Ana Barabash; Cristina Fernández; Carmen De Ugarte; José Antonio Cabranes Journal: Eur J Nucl Med Mol Imaging Date: 2003-08-15 Impact factor: 9.236
Authors: Oscar L Lopez; Lewis H Kuller; Annette Fitzpatrick; Diane Ives; James T Becker; Norman Beauchamp Journal: Neuroepidemiology Date: 2003 Jan-Feb Impact factor: 3.282
Authors: Katherine E Nutter-Upham; Andrew J Saykin; Laura A Rabin; Robert M Roth; Heather A Wishart; Nadia Pare; Laura A Flashman Journal: Arch Clin Neuropsychol Date: 2008-03-12 Impact factor: 2.813
Authors: Caterina Rosano; Vijay K Venkatraman; Jack Guralnik; Anne B Newman; Nancy W Glynn; Lenore Launer; Christopher A Taylor; Jeff Williamson; Stephanie Studenski; Marco Pahor; Howard Aizenstein Journal: J Gerontol A Biol Sci Med Sci Date: 2010-03-26 Impact factor: 6.053
Authors: Caterina Rosano; Yue-Fang Chang; Lewis H Kuller; Jack M Guralnik; Stephanie A Studenski; Howard J Aizenstein; Peter J Gianaros; Oscar L Lopez; William T Longstreth; Anne B Newman Journal: Psychosom Med Date: 2013-07-25 Impact factor: 4.312
Authors: Laura A Rabin; Andrew J Saykin; John D West; Marlana J Borgos; Heather A Wishart; Katherine E Nutter-Upham; Laura A Flashman; Robert B Santulli Journal: Brain Imaging Behav Date: 2009-06 Impact factor: 3.978