K Hestad1, B Kveberg, K Engedal. 1. Department of Psychology, NTNU - Norwegian University of Science and Technology, Trondheim, Norway. knut.hestad@svtntnu.no
Abstract
OBJECTIVE: To study the correlates of cognitive deficits in persons 80 years and older. MATERIALS AND METHODS: Data from 271 individuals between 80 and 102 years of age, drawn from a central registrar (response rate 50%) were analyzed regarding e apolipoprotein E (Apo-E) polymorphism, blood pressure (BP), homocysteine, sex, age and education as predictors for low score on Mini Mental Status Examination (MMSE). RESULTS: Low systolic and diastolic BP were highly associated with low score on the MMSE, followed by age and Apo-E e4. No relationship was found between Apo-E allele groups and BP. Homocysteine, sex, and education were only of marginal importance. CONCLUSIONS: Hypotension is an important factor for performance on the MMSE. To some extent, this was also true for having the Apo-E e4 allele. A combined effect on cognition for these two factors was not found.
OBJECTIVE: To study the correlates of cognitive deficits in persons 80 years and older. MATERIALS AND METHODS: Data from 271 individuals between 80 and 102 years of age, drawn from a central registrar (response rate 50%) were analyzed regarding e apolipoprotein E (Apo-E) polymorphism, blood pressure (BP), homocysteine, sex, age and education as predictors for low score on Mini Mental Status Examination (MMSE). RESULTS: Low systolic and diastolic BP were highly associated with low score on the MMSE, followed by age and Apo-E e4. No relationship was found between Apo-E allele groups and BP. Homocysteine, sex, and education were only of marginal importance. CONCLUSIONS:Hypotension is an important factor for performance on the MMSE. To some extent, this was also true for having the Apo-E e4 allele. A combined effect on cognition for these two factors was not found.
Authors: L B Hoffman; J Schmeidler; G T Lesser; M S Beeri; D P Purohit; H T Grossman; V Haroutunian Journal: Neurology Date: 2009-02-18 Impact factor: 9.910
Authors: Vanessa de Jesus R de Paula; Fabiana Meira Guimarães; Breno Satler Diniz; Orestes Vicente Forlenza Journal: Dement Neuropsychol Date: 2009 Jul-Sep