Marie-Thérèse Genot1, Jean Klastersky. 1. Laboratoire d'Investigation Clinique H.J. Tagnon, Institut Jules Bordet, Centre des Tumeurs, Université Libre de Bruxelles, Bruxelles, Belgium.
Abstract
PURPOSE OF REVIEW: Oral mucositis is a common morbid condition associated with chemotherapy or radiotherapy for which there is no standard prophylaxis or treatment. There is increasing evidence that the use of low-level laser can reduced the severity of mucositis associated with chemotherapy or radiation therapy. The purpose of this review is to examine the available evidence for it. RECENT FINDINGS: For most approaches commonly used to prevent or treat chemotherapy-associated or radiotherapy-associated oral mucositis, a recent panel of experts could not find sufficient levels of evidence to recommend or suggest their use. As for low-level laser therapy, the results are difficult to assess and compare because of interoperator variability and because clinical trials are difficult to conduct in that field. Nevertheless, there is accumulating evidence in support of low-level laser therapy. SUMMARY: On the basis of literature data, it is reasonable to conclude that the evidence that low-level laser therapy may be useful in decreasing the severity of chemotherapy-associated or radiotherapy-associated mucositis is substantial, even though there have been few controlled studies in the field of prevention.
PURPOSE OF REVIEW: Oral mucositis is a common morbid condition associated with chemotherapy or radiotherapy for which there is no standard prophylaxis or treatment. There is increasing evidence that the use of low-level laser can reduced the severity of mucositis associated with chemotherapy or radiation therapy. The purpose of this review is to examine the available evidence for it. RECENT FINDINGS: For most approaches commonly used to prevent or treat chemotherapy-associated or radiotherapy-associated oral mucositis, a recent panel of experts could not find sufficient levels of evidence to recommend or suggest their use. As for low-level laser therapy, the results are difficult to assess and compare because of interoperator variability and because clinical trials are difficult to conduct in that field. Nevertheless, there is accumulating evidence in support of low-level laser therapy. SUMMARY: On the basis of literature data, it is reasonable to conclude that the evidence that low-level laser therapy may be useful in decreasing the severity of chemotherapy-associated or radiotherapy-associated mucositis is substantial, even though there have been few controlled studies in the field of prevention.
Authors: M T Genot-Klastersky; J Klastersky; F Awada; A Awada; P Crombez; M D Martinez; M F Jaivenois; M Delmelle; G Vogt; N Meuleman; M Paesmans Journal: Support Care Cancer Date: 2008-05-06 Impact factor: 3.603
Authors: Mark M Schubert; Fernanda P Eduardo; Katherine A Guthrie; Jean-Claude Franquin; Rene-Jean J Bensadoun; Cesar A Migliorati; C Michele E Lloid; Carlos P Eduardo; Niccoli-Filho Walter; Marcia M Marques; Mohd Hamdi Journal: Support Care Cancer Date: 2007-03-29 Impact factor: 3.603
Authors: Changyu Zheng; Ana P Cotrim; Abraham N Sunshine; Takayuki Sugito; Lina Liu; Anastasia Sowers; James B Mitchell; Bruce J Baum Journal: Clin Cancer Res Date: 2009-07-07 Impact factor: 12.531
Authors: Alyne Simões; José Nicolau; Douglas Nesadal de Souza; Leila Soares Ferreira; Carlos de Paula Eduardo; Christian Apel; Norbert Gutknecht Journal: Clin Oral Investig Date: 2007-07-12 Impact factor: 3.573