Literature DB >> 15817550

Prophylaxis and follow-up after possible exposure to HIV, hepatitis B virus, and hepatitis C virus outside hospital: evaluation of policy 2000-3.

Gerard J B Sonder1, Rosa M Regez, Kees Brinkman, Jan M Prins, Jan-Willem Mulder, Joke Spaargaren, Roel A Coutinho, Anneke van den Hoek.   

Abstract

PROBLEM: Prophylactic treatment and follow-up after exposure to HIV, hepatitis B, and hepatitis C outside hospital needs to be improved. BACKGROUND AND
SETTING: Until January 2000, people in Amsterdam could report exposure outside hospital to either a hospital or the municipal health service. If they reported to the municipal health service, they were then referred to hospitals for HIV prophylaxis, whereas the municipal health service handled treatment and follow-up related to hepatitis B and hepatitis C and traced sources. For cases reported to a hospital, hospital staff often did not trace HIV sources or follow up patients for hepatitis B and hepatitis C. KEY MEASURES FOR IMPROVEMENT: Providing adequate treatment for HIV, hepatitis B and hepatitis C after exposure for all reported exposures outside hospital. STRATEGIES FOR CHANGE: On 1 January 2000, a new protocol was introduced in which three Amsterdam hospitals and the municipal health service collaborated in the treatment and follow-up of exposures outside hospital. Both municipal health service and hospitals can decide whether HIV prophylaxis is necessary and prescribe accordingly. All people exposed in the community who report to hospitals are subsequently referred to the municipal health service for further treatment and follow-up. EFFECTS OF CHANGE: The protocol is effective in that most people comply with treatment and follow-up. When indicated, HIV prophylaxis is started soon after exposure. In nearly two thirds of cases the municipal health service traced and tested the source. LESSONS LEARNT: Provision of treatment and follow-up in one place enables treatment, tracing and testing sources, and follow-up, including counselling and registration of all reported exposures in Amsterdam, which allows for swift identification of emerging epidemiological trends. Since May 2004 all Amsterdam hospitals have participated in the protocol.

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Year:  2005        PMID: 15817550      PMCID: PMC556075          DOI: 10.1136/bmj.330.7495.825

Source DB:  PubMed          Journal:  BMJ        ISSN: 0959-8138


  7 in total

1.  Post-exposure prophylaxis.

Authors:  Marchina E van der Ende; Rosa M Regez; Gerrit Schreij; Jan T M van der Meer; Sven A Danner
Journal:  Int J STD AIDS       Date:  2002-12       Impact factor: 1.359

2.  The need to harmonise management of HIV exposure in Europe.

Authors:  Roland Tubiana
Journal:  Euro Surveill       Date:  2004-06

3.  Postexposure treatment of people exposed to the human immunodeficiency virus through sexual contact or injection-drug use.

Authors:  M H Katz; J L Gerberding
Journal:  N Engl J Med       Date:  1997-04-10       Impact factor: 91.245

4.  Feasibility of postexposure prophylaxis (PEP) against human immunodeficiency virus infection after sexual or injection drug use exposure: the San Francisco PEP Study.

Authors:  J O Kahn; J N Martin; M E Roland; J D Bamberger; M Chesney; D Chambers; K Franses; T J Coates; M H Katz
Journal:  J Infect Dis       Date:  2001-02-01       Impact factor: 5.226

5.  Post-exposure prophylaxis after non-occupational HIV exposure: impact of recommendations on physicians' experiences and attitudes.

Authors:  Anne Laporte; Nathalie Jourdan; Elisabeth Bouvet; Franck Lamontagne; Josiane Pillonel; Jean-Claude Desenclos
Journal:  AIDS       Date:  2002-02-15       Impact factor: 4.177

6.  Proposed recommendations for the management of HIV post-exposure prophylaxis after sexual, injecting drug or other exposures in Europe.

Authors:  J Almeda; J Casabona; B Simon; M Gerard; D Rey; V Puro; T Thomas
Journal:  Euro Surveill       Date:  2004-06

7.  Post-exposure prophylaxis for non-occupational exposure to HIV: current clinical practice and opinions in the UK.

Authors:  C M Giele; R Maw; C A Carne; B G Evans
Journal:  Sex Transm Infect       Date:  2002-04       Impact factor: 3.519

  7 in total
  1 in total

Review 1.  Hepatitis infection in the treatment of opioid dependence and abuse.

Authors:  Thomas F Kresina; Diana Sylvestre; Leonard Seeff; Alain H Litwin; Kenneth Hoffman; Robert Lubran; H Westley Clark
Journal:  Subst Abuse       Date:  2008-04-28
  1 in total

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