PURPOSE: To determine the relationship between various parameters derived from lung dose-volume histogram analysis and the risk of symptomatic radiation pneumonitis (RP) in patients undergoing radical radiotherapy for primary lung cancer. METHODS AND MATERIALS: The records of 156 patients with lung cancer who had been treated with radical radiotherapy (>/=45 Gy) and for whom dose-volume histogram data were available were reviewed. The incidence of symptomatic RP was correlated with a variety of parameters derived from the dose-volume histogram data, including the volume of lung receiving 10 Gy (V(10)) through 50 Gy (V(50)) and the mean lung dose (MLD). RESULTS: The rate of RP at 6 months was 15% (95% confidence interval 9-22%). On univariate analysis, only V(30) (p = 0.036) and MLD (p = 0.043) were statistically significantly related to RP. V(30) correlated highly positively with MLD (r = 0.96, p < 0.001). CONCLUSION: V(30) and MLD can be used to predict the risk of RP in lung cancer patients undergoing radical radiotherapy.
PURPOSE: To determine the relationship between various parameters derived from lung dose-volume histogram analysis and the risk of symptomatic radiation pneumonitis (RP) in patients undergoing radical radiotherapy for primary lung cancer. METHODS AND MATERIALS: The records of 156 patients with lung cancer who had been treated with radical radiotherapy (>/=45 Gy) and for whom dose-volume histogram data were available were reviewed. The incidence of symptomatic RP was correlated with a variety of parameters derived from the dose-volume histogram data, including the volume of lung receiving 10 Gy (V(10)) through 50 Gy (V(50)) and the mean lung dose (MLD). RESULTS: The rate of RP at 6 months was 15% (95% confidence interval 9-22%). On univariate analysis, only V(30) (p = 0.036) and MLD (p = 0.043) were statistically significantly related to RP. V(30) correlated highly positively with MLD (r = 0.96, p < 0.001). CONCLUSION: V(30) and MLD can be used to predict the risk of RP in lung cancerpatients undergoing radical radiotherapy.
Authors: Lawrence B Marks; Soren M Bentzen; Joseph O Deasy; Feng-Ming Spring Kong; Jeffrey D Bradley; Ivan S Vogelius; Issam El Naqa; Jessica L Hubbs; Joos V Lebesque; Robert D Timmerman; Mary K Martel; Andrew Jackson Journal: Int J Radiat Oncol Biol Phys Date: 2010-03-01 Impact factor: 7.038
Authors: Ellen X Huang; Andrew J Hope; Patricia E Lindsay; Marco Trovo; Issam El Naqa; Joseph O Deasy; Jeffrey D Bradley Journal: Acta Oncol Date: 2010-09-28 Impact factor: 4.089
Authors: Jingfang Mao; Zafer Kocak; Sumin Zhou; Jennifer Garst; Elizabeth S Evans; Junan Zhang; Nicole A Larrier; Donna R Hollis; Rodney J Folz; Lawrence B Marks Journal: Int J Radiat Oncol Biol Phys Date: 2007-02-02 Impact factor: 7.038
Authors: Zafer Kocak; Gerben R Borst; Jing Zeng; Sumin Zhou; Donna R Hollis; Junan Zhang; Elizabeth S Evans; Rodney J Folz; Terrence Wong; Daniel Kahn; Jose S A Belderbos; Joos V Lebesque; Lawrence B Marks Journal: Int J Radiat Oncol Biol Phys Date: 2007-01-01 Impact factor: 7.038
Authors: Hekun Jin; Susan L Tucker; Hui Helen Liu; Xiong Wei; Sue Sun Yom; Shulian Wang; Ritsuko Komaki; Yuhchyau Chen; Mary K Martel; Radhe Mohan; James D Cox; Zhongxing Liao Journal: Radiother Oncol Date: 2008-10-18 Impact factor: 6.280