Fan Xue1, Yincheng Zhang, Feng Liu, Jie Jing, Min Ma. 1. Department of Stomatology, Affiliated Hospital of Ningxia Medical College, Ningxia 750004, China. xuefan99@yahoo.com.cn
Abstract
BACKGROUND: The aim of the present work was to study the potential effect of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and neural cell adhesion molecule (NCAM) of immunoglobulin superfamily on the invasion and metastasis of salivary adenoid cystic carcinoma (SACC). METHOD: The expressions of ICAM-1, VCAM-1 and NCAM of forty cases with SACC were examined by immunohistochemical methods using respective kits. RESULTS: A significant relation showed between the expression level and histological differentiation, expression of ICAM-1 and VCAM-1 in solid SACC was greatly increased compared with NCAM; SACC with metastatic lymph node or local recurrence displayed significant relationship to the up-regulation of ICAM-1 and VCAM-1, and to the down-regulation of NCAM. CONCLUSIONS: It is proposed that ICAM-1 and VCAM-1 may play a role in the invasion and metastasis of SACC. NCAM may be an invasion-resistant adhesion molecule.
BACKGROUND: The aim of the present work was to study the potential effect of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and neural cell adhesion molecule (NCAM) of immunoglobulin superfamily on the invasion and metastasis of salivary adenoid cystic carcinoma (SACC). METHOD: The expressions of ICAM-1, VCAM-1 and NCAM of forty cases with SACC were examined by immunohistochemical methods using respective kits. RESULTS: A significant relation showed between the expression level and histological differentiation, expression of ICAM-1 and VCAM-1 in solid SACC was greatly increased compared with NCAM; SACC with metastatic lymph node or local recurrence displayed significant relationship to the up-regulation of ICAM-1 and VCAM-1, and to the down-regulation of NCAM. CONCLUSIONS: It is proposed that ICAM-1 and VCAM-1 may play a role in the invasion and metastasis of SACC. NCAM may be an invasion-resistant adhesion molecule.
Authors: S Doumas; J C Paterson; P M Norris; J V Tighe; L Newman; B S Bisase; A E Kolokotronis; A W Barrett Journal: Oral Maxillofac Surg Date: 2014-07-11
Authors: Nancy Bueno Figueiredo; Sílvia Helena Cestari; Sandro José Conde; Renata Azevedo Melo Luvizotto; Maria Teresa De Sibio; Denise Perone; Maria Lúcia Hirata Katayama; Dirce Maria Carraro; Helena Paula Brentani; Maria Mitzi Brentani; Célia Regina Nogueira Journal: ScientificWorldJournal Date: 2014-01-23