Literature DB >> 15816770

Nonparallelism between reaction rate and dienophile-catalyst affinity in catalytic enantioselective Diels-Alder reactions.

Do Hyun Ryu1, Gang Zhou, E J Corey.   

Abstract

[reaction: see text] The above reaction is much faster with Y = CF(3)CH(2)O than with Y = CH(3)O. However, the methyl ester is a strong inhibitor of the Diels-Alder reaction of the trifluoroethyl ester, since it has a higher affinity for the catalyst 1.

Entities:  

Year:  2005        PMID： 15816770     DOI： 10.1021/ol0503236

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  1 in total

1.  How similar are enzyme active site geometries derived from quantum mechanical theozymes to crystal structures of enzyme-inhibitor complexes? Implications for enzyme design.

Authors:  Jason Dechancie; Fernando R Clemente; Adam J T Smith; Hakan Gunaydin; Yi-Lei Zhao; Xiyun Zhang; K N Houk
Journal:  Protein Sci       Date:  2007-09       Impact factor: 6.725
  1 in total

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