| Literature DB >> 15816731 |
E J Alvarez-Manzaneda1, R Chahboun, I Barranco Pérez, E Cabrera, E Alvarez, R Alvarez-Manzaneda.
Abstract
[reaction: see text] A new route toward puupehenone-related bioactive metabolites from (-)-sclareol, based on the palladium(II)-mediated diastereoselective cyclization of a drimenylphenol, is described. Utilizing this, the first enantiospecific synthesis of the antitumor and antimalarial (-)-15-oxopuupehenol, together with improved syntheses of (+)-puupehenone, (+)-puupehedione, and (+)-15-cyanopuupehenone, were accomplished.Entities:
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Year: 2005 PMID： 15816731 DOI： 10.1021/ol047332j
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005