Literature DB >> 15815044

Long-lasting CD3+ T-cell deficiency after cord blood stem cell transplantation in a human herpesvirus 6-infected child.

Manola Comar1, Pierlanfranco D'Agaro, Douglas Horejsh, Monica Galvan, Simona Fiorentini, Marino Andolina, Arnaldo Caruso, Dario Di Luca, Cesare Campello.   

Abstract

We report a long-lasting (8-month) reactivation of human herpesvirus 6 (HHV-6) infection in child who had undergone cord blood stem cell transplantation. The reactivation was characterized by high viral loads and by immediate-early mRNA positivity. HHV-6 infection was associated with a deep depletion of CD3, while the CD4/CD8 ratio remained substantially unchanged.

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Year:  2005        PMID： 15815044      PMCID： PMC1081381          DOI： 10.1128/JCM.43.4.2002-2003.2005

Source DB:  PubMed          Journal:  J Clin Microbiol        ISSN： 0095-1137            Impact factor:   5.948


  8 in total

Review 1.  Human herpesvirus 6.

Authors:  D K Braun; G Dominguez; P E Pellett
Journal:  Clin Microbiol Rev       Date:  1997-07       Impact factor: 26.132

2.  Temporal mapping of transcripts in herpesvirus 6 variants.

Authors:  P Mirandola; P Menegazzi; S Merighi; T Ravaioli; E Cassai; D Di Luca
Journal:  J Virol       Date:  1998-05       Impact factor: 5.103

3.  Monitoring of active HHV-6 infection in bone marrow transplant recipients by real time PCR; comparison to detection of viral DNA in plasma by qualitative PCR.

Authors:  Masaru Ihira; Tetsushi Yoshikawa; Kyoko Suzuki; Masahiro Ohashi; Sadao Suga; Keizo Horibe; Naoko Tanaka; Hiroshi Kimura; Seiji Kojima; Koji Kato; Takaharu Matsuyama; Yukihiro Nishiyama; Yoshizo Asano
Journal:  Microbiol Immunol       Date:  2002       Impact factor: 1.955

4.  High incidence of human herpesvirus 6 infection with a high viral load in cord blood stem cell transplant recipients.

Authors:  Junji Sashihara; Keiko Tanaka-Taya; Shinya Tanaka; Kiyoko Amo; Hiromi Miyagawa; Gaku Hosoi; Tomokuni Taniguchi; Takafumi Fukui; Naoki Kasuga; Toshiya Aono; Masahiro Sako; Junichi Hara; Koichi Yamanishi; Shintaro Okada
Journal:  Blood       Date:  2002-09-15       Impact factor: 22.113

5.  Hemorrhagic cystitis in children undergoing bone marrow transplantation: a putative role for simian virus 40.

Authors:  Manola Comar; Pierlanfranco D'Agaro; Marino Andolina; Natasha Maximova; Fernanda Martini; Mauro Tognon; Cesare Campello
Journal:  Transplantation       Date:  2004-08-27       Impact factor: 4.939

6.  Pathogenic effects of human herpesvirus 6 in human lymphoid tissue ex vivo.

Authors:  Jean-Charles Grivel; Fabio Santoro; Silvia Chen; Giovanni Fagá; Mauro S Malnati; Yoshinori Ito; Leonid Margolis; Paolo Lusso
Journal:  J Virol       Date:  2003-08       Impact factor: 5.103

7.  Human herpesvirus (HHV)-6 and HHV-7: two closely related viruses with different infection profiles in stem cell transplantation recipients.

Authors:  David Boutolleau; Caroline Fernandez; Elisabeth André; Berthe-Marie Imbert-Marcille; Noël Milpied; Henri Agut; Agnès Gautheret-Dejean
Journal:  J Infect Dis       Date:  2003-01-06       Impact factor: 5.226

8.  U94 of human herpesvirus 6 is expressed in latently infected peripheral blood mononuclear cells and blocks viral gene expression in transformed lymphocytes in culture.

Authors:  A Rotola; T Ravaioli; A Gonelli; S Dewhurst; E Cassai; D Di Luca
Journal:  Proc Natl Acad Sci U S A       Date:  1998-11-10       Impact factor: 11.205
  8 in total
  4 in total

1.  Downregulation of the T-cell receptor complex and impairment of T-cell activation by human herpesvirus 6 u24 protein.

Authors:  Brian M Sullivan; Laurent Coscoy
Journal:  J Virol       Date:  2007-10-31       Impact factor: 5.103

2.  U94 of human herpesvirus 6 inhibits in vitro angiogenesis and lymphangiogenesis.

Authors:  Arnaldo Caruso; Elisabetta Caselli; Simona Fiorentini; Antonella Rotola; Alberto Prandini; Emirena Garrafa; Elisa Saba; Giulio Alessandri; Enzo Cassai; Dario Di Luca
Journal:  Proc Natl Acad Sci U S A       Date:  2009-11-16       Impact factor: 11.205

3.  Immune cells subpopulations in cerebrospinal fluid and peripheral blood of patients with Aneurysmal Subarachnoid Hemorrhage.

Authors:  Leandro Moraes; Sofía Grille; Paula Morelli; Rafael Mila; Natalia Trias; Andreína Brugnini; Natalia LLuberas; Alberto Biestro; Daniela Lens
Journal:  Springerplus       Date:  2015-04-23

Review 4.  Lymphoproliferative Syndromes Associated with Human Herpesvirus-6A and Human Herpesvirus-6B.

Authors:  Eva Eliassen; Gerhard Krueger; Mario Luppi; Dharam Ablashi
Journal:  Mediterr J Hematol Infect Dis       Date:  2018-05-01       Impact factor: 2.576
  4 in total

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