BACKGROUND: Many elderly persons report that they have difficulties learning new things and remembering names, plans, and conversations. Because decreased cognitive function in elderly persons is potentially related to their poor nutritional status, provision of essential nutrients may improve cognitive function. The authors wanted to determine whether consumption of an enriched drink, including moderate doses of all essential micronutrients, improves cognitive function in frail elderly persons. METHODS:Frail, white adults (n=101) who were aged 65 years or older with a body mass index<or=25 kg/m2 were selected for this randomized, double-blind, placebo-controlled trial. They received either an enriched drink or a placebo product for 6 months. Before and after the intervention, participants' cognitive function was assessed (word learning test [WLT], WLT delayed, category fluency [CF] for animals and professions, and recognition memory test for words [RMTW]) and blood biochemical analyses (vitamin B12, homocysteine) were performed. RESULTS:Sixty-seven residents completed the study period. After 6 months, significant differences were noted in changes of the WLT (0.9+/-0.3 vs -0.1+/-0.3; p=.014) and CF professions (1.2+/-0.7 vs -0.6+/-0.5; p=.017) in the supplement group (n=34) compared with the placebo group (n=33). No significant differences were observed in WLT delayed, RMTW, and CF animals. The plasma vitamin B12 concentration increased (105+/-50 vs 8 +/-16; p=.003) and the homocysteine concentration decreased (-6.3+/-5.9 vs -0.3+/-2.9; p=.000) in the supplement group compared with the placebo group. CONCLUSIONS: This study contributes to the evidence that nutritional supplementation may improve neuropsychological performance in frail elderly persons.
RCT Entities:
BACKGROUND: Many elderly persons report that they have difficulties learning new things and remembering names, plans, and conversations. Because decreased cognitive function in elderly persons is potentially related to their poor nutritional status, provision of essential nutrients may improve cognitive function. The authors wanted to determine whether consumption of an enriched drink, including moderate doses of all essential micronutrients, improves cognitive function in frail elderly persons. METHODS: Frail, white adults (n=101) who were aged 65 years or older with a body mass index<or=25 kg/m2 were selected for this randomized, double-blind, placebo-controlled trial. They received either an enriched drink or a placebo product for 6 months. Before and after the intervention, participants' cognitive function was assessed (word learning test [WLT], WLT delayed, category fluency [CF] for animals and professions, and recognition memory test for words [RMTW]) and blood biochemical analyses (vitamin B12, homocysteine) were performed. RESULTS: Sixty-seven residents completed the study period. After 6 months, significant differences were noted in changes of the WLT (0.9+/-0.3 vs -0.1+/-0.3; p=.014) and CF professions (1.2+/-0.7 vs -0.6+/-0.5; p=.017) in the supplement group (n=34) compared with the placebo group (n=33). No significant differences were observed in WLT delayed, RMTW, and CF animals. The plasma vitamin B12 concentration increased (105+/-50 vs 8 +/-16; p=.003) and the homocysteine concentration decreased (-6.3+/-5.9 vs -0.3+/-2.9; p=.000) in the supplement group compared with the placebo group. CONCLUSIONS: This study contributes to the evidence that nutritional supplementation may improve neuropsychological performance in frail elderly persons.
Authors: Hiroko H Dodge; Yuriko Katsumata; Hidemi Todoriki; Shoutoku Yasura; D Craig Willcox; Gene L Bowman; Bradley Willcox; Scott Leonard; Aaron Clemons; Barry S Oken; Jeffrey A Kaye; Maret G Traber Journal: J Gerontol A Biol Sci Med Sci Date: 2010-07-19 Impact factor: 6.053
Authors: A Salva; L Coll-Planas; S Bruce; L De Groot; S Andrieu; G Abellan; B Vellas; Sandrine Andrieu; Luisa Bartorelli; Ytshal N Berner; Stuart Bruce; Bruno Corman; Alex Domingo; Thomas P Egger; Lisette de Groot; Yves Guigoz; Ana Imedio; Mercè Planas; Concha Porras; Joan Carles Rovira; Antoni Salvà; José Antonio Serra; Bruno Vellas Journal: J Nutr Health Aging Date: 2009-06 Impact factor: 4.075
Authors: M Manders; L C P G M De Groot; W H L Hoefnagels; R A M Dhonukshe-Rutten; W Wouters-Wesseling; A J M J Mulders; W A Van Staveren Journal: J Nutr Health Aging Date: 2009-11 Impact factor: 4.075
Authors: Anne Ws Rutjes; David A Denton; Marcello Di Nisio; Lee-Yee Chong; Rajesh P Abraham; Aalya S Al-Assaf; John L Anderson; Muzaffar A Malik; Robin Wm Vernooij; Gabriel Martínez; Naji Tabet; Jenny McCleery Journal: Cochrane Database Syst Rev Date: 2018-12-17
Authors: Jenny McCleery; Rajesh P Abraham; David A Denton; Anne Ws Rutjes; Lee-Yee Chong; Aalya S Al-Assaf; Daniel J Griffith; Shireen Rafeeq; Hakan Yaman; Muzaffar A Malik; Marcello Di Nisio; Gabriel Martínez; Robin Wm Vernooij; Naji Tabet Journal: Cochrane Database Syst Rev Date: 2018-11-01
Authors: Geraldine McNeill; Alison Avenell; Marion K Campbell; Jonathan A Cook; Philip C Hannaford; Mary M Kilonzo; Anne C Milne; Craig R Ramsay; D Gwyn Seymour; Audrey I Stephen; Luke D Vale Journal: Nutr J Date: 2007-05-02 Impact factor: 3.271