Literature DB >> 15814846

The search for safer glucocorticoid receptor ligands.

Jonathan Rosen1, Jeffrey N Miner.   

Abstract

Steroidal glucocorticoids are commonly used due to their powerful antiinflammatory activity. However, despite their excellent efficacy, severe side effects frequently limit the use of these drugs. The search for novel glucocorticoids with reduced side effects has been intensified by the discovery of new molecular details regarding the function of the glucocorticoid receptor. These new insights may pave the way for novel, safer therapies that retain the efficacy of currently prescribed steroids.

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Year:  2005        PMID： 15814846     DOI： 10.1210/er.2005-0002

Source DB:  PubMed          Journal:  Endocr Rev        ISSN： 0163-769X            Impact factor:   19.871


  52 in total

Review 1.  Corticosteroids and muscle wasting: role of transcription factors, nuclear cofactors, and hyperacetylation.

Authors:  Per-Olof Hasselgren; Nima Alamdari; Zaira Aversa; Patricia Gonnella; Ira J Smith; Steven Tizio
Journal:  Curr Opin Clin Nutr Metab Care       Date:  2010-07       Impact factor: 4.294

Review 2.  Tissue-specific glucocorticoid action: a family affair.

Authors:  Katherine L Gross; John A Cidlowski
Journal:  Trends Endocrinol Metab       Date:  2008-09-19       Impact factor: 12.015

Review 3.  Crosstalk in inflammation: the interplay of glucocorticoid receptor-based mechanisms and kinases and phosphatases.

Authors:  Ilse M E Beck; Wim Vanden Berghe; Linda Vermeulen; Keith R Yamamoto; Guy Haegeman; Karolien De Bosscher
Journal:  Endocr Rev       Date:  2009-11-04       Impact factor: 19.871

4.  Structures and mechanism for the design of highly potent glucocorticoids.

Authors:  Yuanzheng He; Wei Yi; Kelly Suino-Powell; X Edward Zhou; W David Tolbert; Xiaobo Tang; Jing Yang; Huaiyu Yang; Jingjing Shi; Li Hou; Hualiang Jiang; Karsten Melcher; H Eric Xu
Journal:  Cell Res       Date:  2014-04-25       Impact factor: 25.617

Review 5.  Ocular surface immunity: homeostatic mechanisms and their disruption in dry eye disease.

Authors:  Stefano Barabino; Yihe Chen; Sunil Chauhan; Reza Dana
Journal:  Prog Retin Eye Res       Date:  2012-03-08       Impact factor: 21.198

6.  Circadian rhythm transcription factor CLOCK regulates the transcriptional activity of the glucocorticoid receptor by acetylating its hinge region lysine cluster: potential physiological implications.

Authors:  Nancy Nader; George P Chrousos; Tomoshige Kino
Journal:  FASEB J       Date:  2009-01-13       Impact factor: 5.191

7.  Dexamethasone-mediated changes in adipose triacylglycerol metabolism are exaggerated, not diminished, in the absence of a functional GR dimerization domain.

Authors:  Donald J Roohk; Smita Mascharak; Cyrus Khambatta; Ho Leung; Marc Hellerstein; Charles Harris
Journal:  Endocrinology       Date:  2013-03-14       Impact factor: 4.736

8.  Doubling the size of the glucocorticoid receptor ligand binding pocket by deacylcortivazol.

Authors:  Kelly Suino-Powell; Yong Xu; Chenghai Zhang; Yong-Guang Tao; W David Tolbert; S Stoney Simons; H Eric Xu
Journal:  Mol Cell Biol       Date:  2007-12-26       Impact factor: 4.272

9.  Identification of an endogenous ligand bound to a native orphan nuclear receptor.

Authors:  Xiaohui Yuan; Tuong Chi Ta; Min Lin; Jane R Evans; Yinchen Dong; Eugene Bolotin; Mark A Sherman; Barry M Forman; Frances M Sladek
Journal:  PLoS One       Date:  2009-05-19       Impact factor: 3.240

10.  BOL-303242-X, a novel selective glucocorticoid receptor agonist, with full anti-inflammatory properties in human ocular cells.

Authors:  Jin-Zhong Zhang; Megan E Cavet; Karl R VanderMeid; Mercedes Salvador-Silva; Francisco J López; Keith W Ward
Journal:  Mol Vis       Date:  2009-12-08       Impact factor: 2.367
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