| Literature DB >> 15814240 |
Jihong Han1, Allison Beeton, Paul Long, Ann Karimova, Alex Robertson, Nigel Cross, Liz Smith, Maura O'Callaghan, Allan Goldman, Kate Brown, Catherine Tuleu.
Abstract
A wet-primed ready-to-use extracorporeal membrane oxygenation (ECMO) circuit is used in some centres for rapid deployment of ECMO during cardiopulmonary resuscitation. Yet, the potential release of plasticizer di(2-ethylhexyl)phthalate (DEHP) from the polyvinyl chloride tubing in the circuit during storage is a concern. In this study, a high performance liquid chromatography method was used to determine the concentration of DEHP in the priming solution (Plasmalyte) from an ECMO circuit stored for up to 14 days at 8 degrees C. No accumulation of DEHP in the circulating fluid was detected. The results provide important information for centres where ECMO circuits are kept wet-primed prior to clinical use.Entities:
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Year: 2005 PMID： 15814240 DOI： 10.1016/j.ijpharm.2005.01.030
Source DB: PubMed Journal: Int J Pharm ISSN： 0378-5173 Impact factor: 5.875