BACKGROUND: Some patients evaluated for chest pain with angiographically normal coronary arteries show coronary slow flow phenomenon (CSFP) on angiography. Slow flow of dye in epicardial coronary arteries is also not an infrequent finding in patients during routine coronary angiography. The precise pathophysiology of CSFP is not known yet. HYPOTHESIS: This study investigates the presence of platelet function disorders in patients with CSFP. METHODS: The patient group included 24 patients with CSFP detected by coronary angiography via the TIMI "frame count" method, and a control group included 23 patients with normal coronary flow. Platelet aggregability induced by use of ristocetin, collagen, and adenosine diphosphate (ADP), was measured from all blood samples in both control and patient groups. RESULTS: The ratio of platelet aggregability increased significantly in patients with CSFP compared with patients with normal coronary flow (ristocetin 57.6 +/- 15 vs. 45.4 +/- 17.1, collagen 62.9 +/- 16.4 vs. 48.9 +/- 25.3, ADP 59.4 +/- 18 vs. 42.4 +/- 15.2, p < 0.05). CONCLUSION: Platelet aggregability is increased in patients with CSFP.
BACKGROUND: Some patients evaluated for chest pain with angiographically normal coronary arteries show coronary slow flow phenomenon (CSFP) on angiography. Slow flow of dye in epicardial coronary arteries is also not an infrequent finding in patients during routine coronary angiography. The precise pathophysiology of CSFP is not known yet. HYPOTHESIS: This study investigates the presence of platelet function disorders in patients with CSFP. METHODS: The patient group included 24 patients with CSFP detected by coronary angiography via the TIMI "frame count" method, and a control group included 23 patients with normal coronary flow. Platelet aggregability induced by use of ristocetin, collagen, and adenosine diphosphate (ADP), was measured from all blood samples in both control and patient groups. RESULTS: The ratio of platelet aggregability increased significantly in patients with CSFP compared with patients with normal coronary flow (ristocetin 57.6 +/- 15 vs. 45.4 +/- 17.1, collagen 62.9 +/- 16.4 vs. 48.9 +/- 25.3, ADP 59.4 +/- 18 vs. 42.4 +/- 15.2, p < 0.05). CONCLUSION: Platelet aggregability is increased in patients with CSFP.
Authors: Aydın Rodi Tosu; Muhsin Kalyoncuoğlu; Halil İbrahim Biter; Sinem Çakal; Beytullah Çakal; Murat Selçuk; Tufan Çinar Journal: Arch Med Sci Atheroscler Dis Date: 2022-07-07
Authors: A Canga; M Cetin; S A Kocaman; M E Durakoğlugil; A Kırbaş; T Erdoğan; A Temiz; A Yılmaz; Y Ciçek Journal: Herz Date: 2013-02-13 Impact factor: 1.443
Authors: Hyun Ju Yoon; Myung Ho Jeong; Sook Hee Cho; Kye Hun Kim; Min Goo Lee; Keun Ho Park; Doo Sun Sim; Nam Sik Yoon; Young Joon Hong; Ju Han Kim; Youngkeun Ahn; Jeong Gwan Cho; Jong Chun Park; Jung Chaee Kang Journal: J Korean Med Sci Date: 2012-05-26 Impact factor: 2.153