| Literature DB >> 15813180 |
Kazuro Shiomi1, Hideaki Ui, Hideaki Suzuki, Hiroko Hatano, Tohru Nagamitsu, Daisuke Takano, Hiroko Miyadera, Tetsuo Yamashita, Kiyoshi Kita, Hideto Miyoshi, Achim Harder, Hiroshi Tomoda, Satoshi Omura.
Abstract
Nafuredin, a delta-lactone antibiotic, is a fungal metabolite showing selective helminth NADH-fumarate reductase inhibition, and whose target had been revealed as complex I. We found that nafuredin is easily converted to nafuredin-gamma by weak alkaline treatment. The structure of nafuredin-gamma was elucidated as a gamma-lactone form of nafuredin with keto-enol tautomerism. Nafuredin-gamma shows similar complex I inhibitory activity as nafuredin, and it also possesses anthelmintic activity in vivo.Entities:
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Year: 2005 PMID： 15813180 DOI： 10.1038/ja.2005.5
Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649