| Literature DB >> 15812536 |
M J D van Tol1, E C J Claas, B Heemskerk, L A Veltrop-Duits, C S de Brouwer, T van Vreeswijk, C C Sombroek, A C M Kroes, M F C Beersma, E P A de Klerk, R M Egeler, A C Lankester, M W Schilham.
Abstract
Human adenoviruses (HAdV) are a frequent cause of potentially fatal infections in patients after allogeneic stem cell transplantation, especially in children. Monitoring of serum/plasma by real-time quantitative PCR is a sensitive tool for the recognition of patients at risk of a potentially fatal infection and for the evaluation of the efficacy of treatment. Data from a retrospective study and from a prospective study demonstrate that recovery of immunity after transplantation is essential for the elimination of HAdV infection. The feasibility of several approaches for the manipulation of immunity in the immunocompromised host to prevent a fatal course of the infection is discussed.Entities:
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Year: 2005 PMID： 15812536 DOI： 10.1038/sj.bmt.1704852
Source DB: PubMed Journal: Bone Marrow Transplant ISSN： 0268-3369 Impact factor: 5.483