Literature DB >> 15811536

CJ-15,801, a fungal natural product, inhibits the intraerythrocytic stage of Plasmodium falciparum in vitro via an effect on pantothenic acid utilisation.

Kevin J Saliba1, Kiaran Kirk.   

Abstract

Entities:  

Mesh：

Substances：

Year:  2005        PMID： 15811536     DOI： 10.1016/j.molbiopara.2005.02.003

Source DB:  PubMed          Journal:  Mol Biochem Parasitol        ISSN： 0166-6851            Impact factor:   1.759


× No keyword cloud information.
  14 in total

Review 1.  Vitamin and cofactor biosynthesis pathways in Plasmodium and other apicomplexan parasites.

Authors:  Sylke Müller; Barbara Kappes
Journal:  Trends Parasitol       Date:  2007-02-02

2.  A pantetheinase-resistant pantothenamide with potent, on-target, and selective antiplasmodial activity.

Authors:  Cristiano J Macuamule; Erick T Tjhin; Collins E Jana; Leanne Barnard; Lizbé Koekemoer; Marianne de Villiers; Kevin J Saliba; Erick Strauss
Journal:  Antimicrob Agents Chemother       Date:  2015-04-06       Impact factor: 5.191

3.  Stereochemical modification of geminal dialkyl substituents on pantothenamides alters antimicrobial activity.

Authors:  Annabelle Hoegl; Hamed Darabi; Elisa Tran; Emelia Awuah; Eleanor S C Kerdo; Eric Habib; Kevin J Saliba; Karine Auclair
Journal:  Bioorg Med Chem Lett       Date:  2014-06-18       Impact factor: 2.823

4.  A class of pantothenic acid analogs inhibits Plasmodium falciparum pantothenate kinase and represses the proliferation of malaria parasites.

Authors:  Christina Spry; Christina L L Chai; Kiaran Kirk; Kevin J Saliba
Journal:  Antimicrob Agents Chemother       Date:  2005-11       Impact factor: 5.191

5.  Triazole Substitution of a Labile Amide Bond Stabilizes Pantothenamides and Improves Their Antiplasmodial Potency.

Authors:  Vanessa M Howieson; Elisa Tran; Annabelle Hoegl; Han Ling Fam; Jonathan Fu; Kate Sivonen; Xiao Xuan Li; Karine Auclair; Kevin J Saliba
Journal:  Antimicrob Agents Chemother       Date:  2016-11-21       Impact factor: 5.191

6.  Structural modification of pantothenamides counteracts degradation by pantetheinase and improves antiplasmodial activity.

Authors:  Marianne de Villiers; Cristiano Macuamule; Christina Spry; Yoo-Min Hyun; Erick Strauss; Kevin J Saliba
Journal:  ACS Med Chem Lett       Date:  2013-06-17       Impact factor: 4.345

7.  The antibiotic CJ-15,801 is an antimetabolite that hijacks and then inhibits CoA biosynthesis.

Authors:  Renier van der Westhuyzen; Justin C Hammons; Jordan L Meier; Samira Dahesh; Wessel J A Moolman; Stephen C Pelly; Victor Nizet; Michael D Burkart; Erick Strauss
Journal:  Chem Biol       Date:  2012-05-25

8.  Identification and functional analysis of the primary pantothenate transporter, PfPAT, of the human malaria parasite Plasmodium falciparum.

Authors:  Yoann Augagneur; Lise Jaubert; Matthieu Schiavoni; Niseema Pachikara; Aprajita Garg; Sahar Usmani-Brown; Donna Wesolowski; Skye Zeller; Abhisek Ghosal; Emmanuel Cornillot; Hamid M Said; Priti Kumar; Sidney Altman; Choukri Ben Mamoun
Journal:  J Biol Chem       Date:  2013-05-31       Impact factor: 5.157

9.  Pantothenamides are potent, on-target inhibitors of Plasmodium falciparum growth when serum pantetheinase is inactivated.

Authors:  Christina Spry; Cristiano Macuamule; Zhiyang Lin; Kristopher G Virga; Richard E Lee; Erick Strauss; Kevin J Saliba
Journal:  PLoS One       Date:  2013-02-06       Impact factor: 3.240

10.  Overcoming synthetic challenges in targeting coenzyme A biosynthesis with the antimicrobial natural product CJ-15,801.

Authors:  Riyad Domingo; Renier van der Westhuyzen; Anton R Hamann; Konrad J Mostert; Leanne Barnard; Tanya Paquet; Erick T Tjhin; Kevin J Saliba; Willem A L van Otterlo; Erick Strauss
Journal:  Medchemcomm       Date:  2019-10-17       Impact factor: 3.597
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.