[Decreased serum protein binding of glymidine in icteric liver disease and its partial correction with charcoal (author's transl].

In patients with hyperbilirubinemic liver disease serum protein binding of the antidiabetic agent glymidine is reduced considerably. After treatment of the serum with charcoal the reduced glymidine binding can be assimilated partly, but not completely, to the glymidine binding in healthy subjects. It may be concluded there from that the reduced glymidine binding in patients with hyperbilirubinemic liver disease has to be partly caused by substances which are retained in the blood of these patients. Besides bilirubin, other substances must be responsible herefore. Bilirubin, when added in vitro to the serum of healthy subjects, is not able to decrease glymidine binding to a degree similar to the results obtained in the patients with liver disease.