Literature DB >> 15808904

Identification of cDNA coding for a homologue to mammalian leptin from pufferfish, Takifugu rubripes.

Tadahide Kurokawa1, Susumu Uji, Tohru Suzuki.   

Abstract

We identified cDNA coding for a homologue to mammalian leptin in puffer, Takifugu rubripes, using genomic synteny around the human leptin gene. In addition to significant sequence homologies, the puffer leptin (pLEP) displays characteristic structural features in common with mammalian leptin. The pLEP mRNA was expressed mostly in the liver that contained abundant lipids. In addition, homologues to pLEP were found in the databanks for three fish species (salmon, medaka, and Tetraodon) and two amphibians (salamander and Xenopus). The phylogenetic analysis shows rapid rates of molecular divergence among leptins from different vertebrate classes, but not between mammals and avians.

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Year:  2005        PMID： 15808904     DOI： 10.1016/j.peptides.2004.12.017

Source DB:  PubMed          Journal:  Peptides        ISSN： 0196-9781            Impact factor:   3.750


  41 in total

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Review 7.  Comparative endocrinology of leptin: assessing function in a phylogenetic context.

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9.  Expression of leptin receptor gene in developing and adult zebrafish.

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10.  Feeding rates affect growth, intestinal digestive and absorptive capabilities and endocrine functions of juvenile blunt snout bream Megalobrama amblycephala.

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Journal:  Fish Physiol Biochem       Date:  2015-11-23       Impact factor: 2.794
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