Literature DB >> 15808787

Effect of cigarette smoking on DNA damage of human cumulus cells analyzed by comet assay.

Ildikó Sinkó1, Mónika Mórocz, János Zádori, Katalin Kokavszky, István Raskó.   

Abstract

Cigarette smoking has been reported to induce intrafollicular oxidative stress that may lead to DNA damage. The purpose of this study was to determine damage in DNA in human cumulus cells caused by tobacco smoke in females who had received in vitro fertilization. The level of DNA damage in freshly isolated cumulus cells was determined by comet assay. Statistically significant increase (p<0.05) was observed in damaged nuclear DNA in smokers, both at basal level and after oxidative stress induced by hydrogen-peroxide. Since cumulus cells have an important role in oocyte maturation, ovulation and fertilization, this method could be used both as a test for the evaluation of the biological potential of the female reproductive system and as a direct means to measure certain toxic effects.

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Year:  2005        PMID： 15808787     DOI： 10.1016/j.reprotox.2004.12.007

Source DB:  PubMed          Journal:  Reprod Toxicol        ISSN： 0890-6238            Impact factor:   3.143


  15 in total

Review 1.  Could oxidative stress influence the in-vitro maturation of oocytes?

Authors:  Catherine M H Combelles; Sajal Gupta; Ashok Agarwal
Journal:  Reprod Biomed Online       Date:  2009-06       Impact factor: 3.828

2.  Brain oxidative damage restored by Sesbania grandiflora in cigarette smoke-exposed rats.

Authors:  Thiyagarajan Ramesh; Chandrabose Sureka; Shanmugham Bhuvana; Vavamohaideen Hazeena Begum
Journal:  Metab Brain Dis       Date:  2015-01-27       Impact factor: 3.584

3.  Modifiable Risk Factors and Infertility: What are the Connections?

Authors:  Brooke V Rossi; Mary Abusief; Stacey A Missmer
Journal:  Am J Lifestyle Med       Date:  2014-12-16

4.  Accompaniment of Time-Lapse Parameters and Cumulus Cell RNA-Sequencing in Embryo Evaluation.

Authors:  Azam Govahi; Fatemehsadat Amjadi; Mohammad-Hossein Nasr-Esfahani; Ehsan Raoufi; Mehdi Mehdizadeh
Journal:  Reprod Sci       Date:  2021-10-12       Impact factor: 3.060

5.  Cumulus cell antioxidant system is modulated by patients' clinical characteristics and correlates with embryo development.

Authors:  Lucia von Mengden; Marco Antônio De Bastiani; Leticia Schmidt Arruda; Carlos Alberto Link; Fábio Klamt
Journal:  J Assist Reprod Genet       Date:  2022-04-26       Impact factor: 3.357

6.  Cigarette smoke-induced DNA damage and repair detected by the comet assay in HPV-transformed cervical cells.

Authors:  Afsoon Moktar; Srivani Ravoori; Manicka V Vadhanam; C Gary Gairola; Ramesh C Gupta
Journal:  Int J Oncol       Date:  2009-12       Impact factor: 5.650

Review 7.  Environmental PAH exposure and male idiopathic infertility: a review on early life exposures and adult diagnosis.

Authors:  Erin P Madeen; David E Williams
Journal:  Rev Environ Health       Date:  2017-03-01       Impact factor: 3.458

8.  Redox Biology of Human Cumulus Cells: Basic Concepts, Impact on Oocyte Quality, and Potential Clinical Use.

Authors:  Lucia von Mengden; Fabio Klamt; Johan Smitz
Journal:  Antioxid Redox Signal       Date:  2020-03-10       Impact factor: 8.401

9.  Cigarette smoke impairs granulosa cell proliferation and oocyte growth after exposure cessation in young Swiss mice: an experimental study.

Authors:  Larissa L O Paixão; Rejane P Gaspar-Reis; Gabrielle P L Gonzalez; Aline S Santos; Aluana C Santana; Rachel M M Santos; Poli Mara Spritzer; Celly Cristina A Nascimento-Saba
Journal:  J Ovarian Res       Date:  2012-09-20       Impact factor: 4.234

10.  Effect of vitamin e on oocytes apoptosis in nicotine-treated mice.

Authors:  Ebrahim Asadi; Mehrdad Jahanshahi; Mohammad Jafar Golalipour
Journal:  Iran J Basic Med Sci       Date:  2012-05       Impact factor: 2.699
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