| Literature DB >> 15808685 |
F J M F Dor1, K Kuwaki, Y-L Tseng, A Shimizu, S L Houser, K Yamada, R J Hawley, C Patience, M Awwad, J A Fishman, S C Robson, D H Sachs, H-J Schuurman, D K C Cooper.
Abstract
Hearts from alpha1,3-Galactosyltransferase gene-knockout (GaIT-KO) pigs were transplanted heterotopically into 8 baboons that received an anti-CD154 monoclonal antibody (mAb)-based immunosuppressive regimen and heparin. Three baboons died or were euthanized with beating grafts on 16, 23, and 56 days, respectively, and the remaining 5 grafts functioned for 59-179 days. Hyperacute rejection did not occur, and classical features of acute humoral xenograft or acute cellular rejection were rare. However, thrombotic microangiopathy (TM) developed in all cases; its onset was delayed in 2 baboons that received aspirin. Function of a pig organ in a baboon for a period approaching 6 months has not been reported previously and lends encouragement that the barriers to xenotransplantation will be overcome, but TM requires investigation.Entities:
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Year: 2005 PMID： 15808685 DOI： 10.1016/j.transproceed.2004.12.235
Source DB: PubMed Journal: Transplant Proc ISSN： 0041-1345 Impact factor: 1.066